Rad23b MGI Mouse Gene Detail - MGI:105128 - RAD23 homolog B, nucleotide excision repair protein

Symbol

Rad23b
Name

RAD23 homolog B, nucleotide excision repair protein
Synonyms

0610007D13Rik, mHR23B

Feature Type

protein coding gene
IDs

MGI:105128
NCBI Gene: 19359
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:55350043-55392237 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 29.70 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

922 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105128	protein coding gene	Chr4:55350042-55392237 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028305	protein coding gene	Chr4:54053198-54098344 (+)
A/J	MGP_AJ_G0028266	protein coding gene	Chr4:51973670-52017353 (+)
AKR/J	MGP_AKRJ_G0028215	protein coding gene	Chr4:53386842-53430149 (+)
BALB/cJ	MGP_BALBcJ_G0028285	protein coding gene	Chr4:52140617-52183748 (+)
C3H/HeJ	MGP_C3HHeJ_G0028006	protein coding gene	Chr4:53915931-53961426 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028726	protein coding gene	Chr4:56000370-56047791 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026034	protein coding gene	Chr4:48848364-48892402 (+)
CAST/EiJ	MGP_CASTEiJ_G0027444	protein coding gene	Chr4:53606336-53653042 (+)
CBA/J	MGP_CBAJ_G0027971	protein coding gene	Chr4:57911052-57959048 (+)
DBA/2J	MGP_DBA2J_G0028121	protein coding gene	Chr4:51903354-51947754 (+)
FVB/NJ	MGP_FVBNJ_G0028088	protein coding gene	Chr4:51129796-51172051 (+)
LP/J	MGP_LPJ_G0028220	protein coding gene	Chr4:54143080-54189141 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028112	protein coding gene	Chr4:61113907-61161308 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028762	protein coding gene	Chr4:53601463-53646620 (+)
PWK/PhJ	MGP_PWKPhJ_G0027169	protein coding gene	Chr4:51881266-51922113 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026997	protein coding gene	Chr4:52886619-52928846 (+)
WSB/EiJ	MGP_WSBEiJ_G0027522	protein coding gene	Chr4:53518078-53565185 (+)

Human Ortholog

RAD23B, RAD23 homolog B, nucleotide excision repair protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAD23B, RAD23 homolog B, nucleotide excision repair protein
Synonyms

HHR23B, HR23B, P58
Links

HGNC:9813

NCBI Gene ID: 5887

neXtProt AC: NX_P54727

UniProt: P54727
Chr Location

9q31.2; chr9:107283137-107332194 (+) GRCh38

MGI Vertebrate Homology

Rad23b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAD23B
Gene Tree

Rad23b

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Phenotype Summary

32 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Endonuclease-mediated

2
Gene trapped

53
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a disruption in this gene usually die around the time of birth. Those that survive show growth retardation, eye, reproductive, behavioral, and digestive system abnormalities. They usually die within 1 year of birth.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

38
cDNA Data

202
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rad23b

ZFIN rad23b

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All Sequences

69
RefSeq

2
UniProt

6
CCDS

CCDS18194.1

Ensembl

ENSMUSG00000028426 (Evidence)
NCBI Gene

19359

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028426	Ensembl Gene Model \| MGI Sequence Detail	42195	C57BL/6J	± kb
transcript	ENSMUST00000030134	Ensembl \| MGI Sequence Detail	3810	Not Applicable
polypeptide	ENSMUSP00000030134	Ensembl \| MGI Sequence Detail	416	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013670 UV excision repair protein RAD23 homolog B

(term hierarchy)
PDB

2F4M, 2F4O
InterPro Domains

IPR006636 Heat shock chaperonin-binding

IPR041811 RAD23A/RAD23B, UBA1 domain

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

IPR004806 UV excision repair protein Rad23

IPR015360 XPC-binding domain

IPR036353 XPC-binding domain superfamily

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All nucleic 206

Genomic 1

cDNA 203

Primer pair 1

Other 1

Microarray probesets 7

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MGD-MRK-32169, MGI:1925602, MGI:2140506

Summaries

All 57

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 14
Earliest

J:30878 van der Spek PJ, et al., Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23. Genomics. 1996 Jan 1;31(1):20-7
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Rad23b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37326	Chr4:55350043-55350078 (+)	18 bp
Tssr37327	Chr4:55351323-55351334 (+)	1,286 bp
Tssr37328	Chr4:55356499-55356534 (+)	6,474 bp
Tssr37329	Chr4:55366810-55366822 (+)	16,773 bp
Tssr37330	Chr4:55368039-55368053 (+)	18,003 bp
Tssr37331	Chr4:55370194-55370337 (+)	20,223 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24