Ptpn3 MGI Mouse Gene Detail - MGI:105307 - protein tyrosine phosphatase, non-receptor type 3

Symbol

Ptpn3
Name

protein tyrosine phosphatase, non-receptor type 3
Synonyms

9530011I20Rik, PTPCL, PTP-H1

Feature Type

protein coding gene
IDs

MGI:105307
NCBI Gene: 545622
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr4:57190841-57301837 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 31.66 cM
Mapping Data

3 experiments

SNPs within 2kb

2747 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105307	protein coding gene	Chr4:57190841-57339036 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028316	protein coding gene	Chr4:55972458-56085355 (-)
A/J	MGP_AJ_G0028277	protein coding gene	Chr4:53841257-53953533 (-)
AKR/J	MGP_AKRJ_G0028226	protein coding gene	Chr4:55328406-55440533 (-)
BALB/cJ	MGP_BALBcJ_G0028296	protein coding gene	Chr4:53993793-54106073 (-)
C3H/HeJ	MGP_C3HHeJ_G0028017	protein coding gene	Chr4:55832836-55946915 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028737	protein coding gene	Chr4:57972106-58084846 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026043	protein coding gene	Chr4:50635326-50746910 (-)
CAST/EiJ	MGP_CASTEiJ_G0027455	protein coding gene	Chr4:55536077-55664285 (-)
CBA/J	MGP_CBAJ_G0027982	protein coding gene	Chr4:59969274-60086512 (-)
DBA/2J	MGP_DBA2J_G0028132	protein coding gene	Chr4:53740880-53852822 (-)
FVB/NJ	MGP_FVBNJ_G0028099	protein coding gene	Chr4:52963722-53083421 (-)
LP/J	MGP_LPJ_G0028231	protein coding gene	Chr4:56084350-56193999 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028123	protein coding gene	Chr4:63109866-63226920 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028773	protein coding gene	Chr4:55507012-55621458 (-)
PWK/PhJ	MGP_PWKPhJ_G0027180	protein coding gene	Chr4:53732729-53847312 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027008	protein coding gene	Chr4:54771764-54895877 (-)
WSB/EiJ	MGP_WSBEiJ_G0027533	protein coding gene	Chr4:55462244-55576894 (-)

Human Ortholog

PTPN3, protein tyrosine phosphatase non-receptor type 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN3, protein tyrosine phosphatase non-receptor type 3
Synonyms

PTP-H1, PTPH1
Links

HGNC:9655

NCBI Gene ID: 5774

neXtProt AC: NX_P26045

UniProt: P26045
Chr Location

9q31.3; chr9:109375466-109538420 (-) GRCh38

MGI Vertebrate Homology

Ptpn3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPN3
Protein SuperFamily

Tyr-Ptase_nr3
Gene Tree

Ptpn3

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Phenotype Summary

3 phenotypes from 4 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

131
Endonuclease-mediated

1
Gene trapped

126
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

170 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased body weight, especially in males, and male mice exhibit increased bone mineral content.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

21
cDNA Data

36
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn3

ZFIN ptpn3

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All Sequences

59
RefSeq

14
UniProt

7
CCDS

CCDS51181.1

Ensembl

ENSMUSG00000038764 (Evidence)
NCBI Gene

545622

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038764	Ensembl Gene Model \| MGI Sequence Detail	110997	C57BL/6J	± kb
transcript	ENSMUST00000075637	Ensembl \| MGI Sequence Detail	6369	Not Applicable
polypeptide	ENSMUSP00000075063	Ensembl \| MGI Sequence Detail	913	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000029701 tyrosine-protein phosphatase non-receptor type 3

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR019749 Band 4.1 domain

IPR000798 Ezrin/radixin/moesin-like

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4

IPR041783 PTPN3/4, FERM domain C-lobe

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 37

cDNA 36

Other 1

Microarray probesets 13

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MGD-MRK-32348, MGI:3026925

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 13
Earliest

J:30499 Messerle M, et al., Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43
Latest

J:344312 Liu H, et al., Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722

TSS for Ptpn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41846	Chr4:57301791-57301828 (-)	27 bp
Tssr41845	Chr4:57301475-57301510 (-)	344 bp
Tssr41844	Chr4:57300751-57300839 (-)	1,042 bp
Tssr41843	Chr4:57300362-57300404 (-)	1,454 bp
Tssr41842	Chr4:57300324-57300358 (-)	1,496 bp
Tssr41841	Chr4:57300304-57300317 (-)	1,526 bp
Tssr41840	Chr4:57290059-57290071 (-)	11,772 bp
Tssr41839	Chr4:57278930-57278934 (-)	22,905 bp
Tssr41838	Chr4:57262661-57262670 (-)	39,171 bp
Tssr41837	Chr4:57262580-57262608 (-)	39,243 bp
Tssr41836	Chr4:57249139-57249150 (-)	52,692 bp
Tssr41835	Chr4:57249112-57249124 (-)	52,719 bp
Tssr41834	Chr4:57241193-57241200 (-)	60,640 bp
Tssr41833	Chr4:57241179-57241192 (-)	60,651 bp
Tssr41832	Chr4:57241122-57241139 (-)	60,706 bp
Tssr41831	Chr4:57241042-57241056 (-)	60,788 bp
Tssr41830	Chr4:57241005-57241008 (-)	60,830 bp
Tssr41829	Chr4:57240993-57241004 (-)	60,838 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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