Pnoc MGI Mouse Gene Detail - MGI:105308

Symbol

Pnoc
Name

prepronociceptin
Synonyms

N23K, N/OFQ, Npnc1, OFQ/N, proorphanin

Feature Type

protein coding gene
IDs

MGI:105308
NCBI Gene: 18155
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:65638931-65662908 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.33 cM, cytoband D1
Mapping Data

1 experiment

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105308	protein coding gene	Chr14:65638122-65662921 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021480	protein coding gene	Chr14:60002544-60031857 (-)
A/J	MGP_AJ_G0021439	protein coding gene	Chr14:58616217-58642263 (-)
AKR/J	MGP_AKRJ_G0021415	protein coding gene	Chr14:60650704-60680361 (-)
BALB/cJ	MGP_BALBcJ_G0021445	protein coding gene	Chr14:58551983-58576657 (-)
C3H/HeJ	MGP_C3HHeJ_G0021222	protein coding gene	Chr14:60296593-60324802 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021884	protein coding gene	Chr14:62780819-62805449 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019424	protein coding gene	Chr14:56546304-56571690 (-)
CAST/EiJ	MGP_CASTEiJ_G0020739	protein coding gene	Chr14:56777989-56804029 (-)
CBA/J	MGP_CBAJ_G0021189	protein coding gene	Chr14:64673273-64697981 (-)
DBA/2J	MGP_DBA2J_G0021312	protein coding gene	Chr14:58265772-58290802 (-)
FVB/NJ	MGP_FVBNJ_G0021291	protein coding gene	Chr14:57665295-57690453 (-)
LP/J	MGP_LPJ_G0021387	protein coding gene	Chr14:61041337-61068263 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021320	protein coding gene	Chr14:63782828-63808553 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021907	protein coding gene	Chr14:59829788-59854714 (-)
PWK/PhJ	MGP_PWKPhJ_G0020483	protein coding gene	Chr14:54973236-54998766 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020316	protein coding gene	Chr14:55792170-55822615 (-)
WSB/EiJ	MGP_WSBEiJ_G0020792	protein coding gene	Chr14:60143615-60169320 (-)

Human Ortholog

PNOC, prepronociceptin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PNOC, prepronociceptin
Synonyms

N/OFQ, NOP, OFQ, PPNOC, ppN/OFQ
Links

HGNC:9163

NCBI Gene ID: 5368

neXtProt AC: NX_Q13519

UniProt: Q13519
Chr Location

8p21.1; chr8:28316986-28343355 (+) GRCh38

MGI Vertebrate Homology

Pnoc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PNOC
Gene Tree

Pnoc

Diseases

1 with human PNOC associations

				Human Disease	Mouse Models
				neonatal abstinence syndrome IDs neonatal abstinence syndrome DOID:9828 DOID:6679 ICD10CM:P96.1 ICD9CM:779.5 MESH:D009357 NCI:C35808 NCI:C87101 UMLS_CUI:C0027609 UMLS_CUI:C1332133

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Pnoc
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

13 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele fail to exhibit prostaglandin E2-induced allodynia. Mice homozygous for a different knock-out allele display increased naloxone-precipitated jumping in response to morphine treatment.

less

All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

81
cDNA Data

12
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pnoc

ZFIN pnoca, pnocb

less

All Sequences

47
RefSeq

8
UniProt

3
CCDS

CCDS27213.1, CCDS88690.1

Ensembl

ENSMUSG00000045731 (Evidence)
NCBI Gene

18155

			Length	Strain/Species	Flank
genomic	18155	NCBI Gene Model \| MGI Sequence Detail	23978	C57BL/6J	± kb
transcript	NM_001424488	RefSeq \| MGI Sequence Detail	1077	C57BL/6
polypeptide	Q64387	UniProt \| EBI \| MGI Sequence Detail	187	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000012940 nociceptin

(term hierarchy)
InterPro Domains

IPR002367 Nociceptin

IPR006024 Opioid neuropeptide precursor

less

All nucleic 15

Genomic 1

cDNA 12

Primer pair 2

Microarray probesets 3

less

MGD-MRK-32349

Summaries

All 73

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 23
Earliest

J:30116 Saito Y, et al., N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochem Biophys Res Commun. 1995 Dec 14;217(2):539-45
Latest

J:332369 Liau ES, et al., Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons. Nat Commun. 2023 Jan 3;14(1):46

TSS for Pnoc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129251	Chr14:65662902-65662915 (-)	-1 bp
Tssr129250	Chr14:65662618-65662637 (-)	280 bp
Tssr129249	Chr14:65642635-65642641 (-)	20,270 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24