Sstr4 MGI Mouse Gene Detail - MGI:105372

Symbol

Sstr4
Name

somatostatin receptor 4
Synonyms

Smstr4, sst4

Feature Type

protein coding gene
IDs

MGI:105372
NCBI Gene: 20608
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:148237297-148238684 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.44 cM
Mapping Data

7 experiments

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105372	protein coding gene	Chr2:148237264-148238687 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026606	protein coding gene	Chr2:152736810-152738233 (+)
A/J	MGP_AJ_G0026570	protein coding gene	Chr2:146527372-146528795 (+)
AKR/J	MGP_AKRJ_G0026544	protein coding gene	Chr2:150758758-150760181 (+)
BALB/cJ	MGP_BALBcJ_G0026582	protein coding gene	Chr2:146946425-146947848 (+)
C3H/HeJ	MGP_C3HHeJ_G0026325	protein coding gene	Chr2:151258511-151259934 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027027	protein coding gene	Chr2:157182843-157184266 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024405	protein coding gene	Chr2:140535296-140536719 (+)
CAST/EiJ	MGP_CASTEiJ_G0025786	protein coding gene	Chr2:151645369-151646792 (+)
CBA/J	MGP_CBAJ_G0026305	protein coding gene	Chr2:162949326-162950749 (+)
DBA/2J	MGP_DBA2J_G0026439	protein coding gene	Chr2:145796991-145798414 (+)
FVB/NJ	MGP_FVBNJ_G0026403	protein coding gene	Chr2:144293330-144294753 (+)
LP/J	MGP_LPJ_G0026543	protein coding gene	Chr2:152854721-152856144 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026423	protein coding gene	Chr2:167021240-167022663 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027082	protein coding gene	Chr2:150765155-150766578 (+)
PWK/PhJ	MGP_PWKPhJ_G0025522	protein coding gene	Chr2:145479559-145480982 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025323	protein coding gene	Chr2:149734825-149736243 (+)
WSB/EiJ	MGP_WSBEiJ_G0025860	protein coding gene	Chr2:151716274-151717697 (+)

Human Ortholog

SSTR4, somatostatin receptor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSTR4, somatostatin receptor 4
Synonyms

SS-4-R, SS4-R, SS4R, SST4
Links

HGNC:11333

NCBI Gene ID: 6754

neXtProt AC: NX_P31391

UniProt: P31391
Chr Location

20p11.21; chr20:23035312-23039237 (+) GRCh38

MGI Vertebrate Homology

Sstr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SSTR4
Gene Tree

Sstr4

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Sstr4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

920
Tissues

79
cDNA Data

7
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sstr4

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS38260.1

Ensembl

ENSMUSG00000037014 (Evidence)
NCBI Gene

20608

			Length	Strain/Species	Flank
genomic	20608	NCBI Gene Model \| MGI Sequence Detail	1388	C57BL/6J	± kb
transcript	NM_009219	RefSeq \| MGI Sequence Detail	1388	ZRU/MplStud
polypeptide	P49660	UniProt \| EBI \| MGI Sequence Detail	385	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001671 somatostatin receptor type 4

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001512 Somatostatin receptor 4

IPR000586 Somatostatin receptor family
GlyGen

P49660 1 site

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All nucleic 16

Genomic 4

cDNA 7

Primer pair 5

Microarray probesets 5

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MGD-MRK-33041

Summaries

All 66

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 22
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sstr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20639	Chr2:148237258-148237276 (+)	-30 bp
Tssr20640	Chr2:148237289-148237333 (+)	14 bp
Tssr20641	Chr2:148237773-148237802 (+)	491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24