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Npy4r Gene Detail
Summary
  • Symbol
    Npy4r
  • Name
    neuropeptide Y receptor Y4
  • Synonyms
    NYYR-D, Ppyr1, Y4
  • Feature Type
    protein coding gene
  • IDs
    MGI:105374
    NCBI Gene: 19065
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33867603-33874376 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105374
 protein coding gene Chr14:33865949-33874446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021167
 protein coding gene Chr14:27482671-27491146 (-)
A/J MGP_AJ_G0021115
 protein coding gene Chr14:26421147-26429644 (-)
AKR/J MGP_AKRJ_G0021092
 protein coding gene Chr14:27596743-27605240 (-)
BALB/cJ MGP_BALBcJ_G0021119
 protein coding gene Chr14:26603756-26612253 (-)
C3H/HeJ MGP_C3HHeJ_G0020902
 protein coding gene Chr14:27510635-27519132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021551
 protein coding gene Chr14:28540113-28548610 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019113
 protein coding gene Chr14:26453965-26462445 (-)
CAST/EiJ MGP_CASTEiJ_G0020427
 protein coding gene Chr14:27327422-27335864 (-)
CBA/J MGP_CBAJ_G0020869
 protein coding gene Chr14:29572725-29581222 (-)
DBA/2J MGP_DBA2J_G0020991
 protein coding gene Chr14:26458608-26467112 (-)
FVB/NJ MGP_FVBNJ_G0020975
 protein coding gene Chr14:26418492-26426989 (-)
LP/J MGP_LPJ_G0021060
 protein coding gene Chr14:27818286-27826761 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021001
 protein coding gene Chr14:28721358-28729855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021584
 protein coding gene Chr14:27430586-27439083 (-)
PWK/PhJ MGP_PWKPhJ_G0020175
 protein coding gene Chr14:25949485-25957980 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019999
 protein coding gene Chr14:27030513-27038986 (-)
WSB/EiJ MGP_WSBEiJ_G0020482
 protein coding gene Chr14:27481335-27489832 (-)



Homology
more
  • Human Ortholog
    NPY4R, neuropeptide Y receptor Y4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY4R, neuropeptide Y receptor Y4
  • Synonyms
    NPY4-R, PP1, PPYR1, Y4
  • Links
    NCBI Gene ID: 5540
    neXtProt AC: NX_P50391
    UniProt: P50391

  • Chr Location
    10q11.22; chr10:46461099-46470668 (-)  GRCh38
  • Human Ortholog
    NPY4R2, neuropeptide Y receptor Y4-2
  • Synonyms
    CH17-360D5.1, NPY4-R, NPY4R, PP1, PPYR1
  • Links
    NCBI Gene ID: 100996758
    neXtProt AC: NX_P0DQD5, NX_P50391
    UniProt: P0DQD5

  • Chr Location
    chr10:47914243-47923524 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased weight, increased drinking behavior, decreased food intake, aggression towards other mice, decreased white adipose tissue, and accelerated lobuloalveolar development during pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19065 NCBI Gene Model | MGI Sequence Detail 6774 C57BL/6J ±  kb
    transcript NM_008919 RefSeq | MGI Sequence Detail 1903 Not Specified  
    polypeptide Q61041 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 4
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33043
    References
    more
    • Summaries
      All 44
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:31619 Gregor P, et al., Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett. 1996 Feb 26;381(1-2):58-62
    • Latest
      J:250627 Aragon F, et al., Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. Biochim Biophys Acta. 2015 Feb;1850(2):343-51
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory