Adam19 MGI Mouse Gene Detail - MGI:105377 - ADAM metallopeptidase domain 19

Symbol

Adam19
Name

ADAM metallopeptidase domain 19
Synonyms

Mltnb

Feature Type

protein coding gene
IDs

MGI:105377
NCBI Gene: 11492
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:45946819-46038170 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 27.54 cM, cytoband A5-B1.1
Mapping Data

6 experiments

SNPs within 2kb

2645 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105377	protein coding gene	Chr11:45945329-46038174 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018188	protein coding gene	Chr11:44943851-45050625 (+)
A/J	MGP_AJ_G0018160	protein coding gene	Chr11:43229505-43321635 (+)
AKR/J	MGP_AKRJ_G0018125	protein coding gene	Chr11:44464496-44560158 (+)
BALB/cJ	MGP_BALBcJ_G0018129	protein coding gene	Chr11:43382934-43478006 (+)
C3H/HeJ	MGP_C3HHeJ_G0017943	protein coding gene	Chr11:44510783-44606861 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018583	protein coding gene	Chr11:46288441-46390187 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016238	protein coding gene	Chr11:41210477-41302547 (+)
CAST/EiJ	MGP_CASTEiJ_G0017506	protein coding gene	Chr11:44626390-44735671 (+)
CBA/J	MGP_CBAJ_G0017915	protein coding gene	Chr11:48457172-48565443 (+)
DBA/2J	MGP_DBA2J_G0018025	protein coding gene	Chr11:42971706-43066903 (+)
FVB/NJ	MGP_FVBNJ_G0018019	protein coding gene	Chr11:42650441-42745863 (+)
LP/J	MGP_LPJ_G0018097	protein coding gene	Chr11:45197173-45297037 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018043	protein coding gene	Chr11:49992035-50099602 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018622	protein coding gene	Chr11:44631308-44727097 (+)
PWK/PhJ	MGP_PWKPhJ_G0017286	protein coding gene	Chr11:43050111-43146517 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017079	protein coding gene	Chr11:44423332-44528826 (+)
WSB/EiJ	MGP_WSBEiJ_G0017556	protein coding gene	Chr11:44332953-44430060 (+)

Human Ortholog

ADAM19, ADAM metallopeptidase domain 19

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAM19, ADAM metallopeptidase domain 19
Synonyms

FKSG34, MADDAM, MLTNB
Links

HGNC:197

NCBI Gene ID: 8728

neXtProt AC: NX_Q9H013

UniProt: Q9H013
Chr Location

5q33.3; chr5:157395534-157575775 (-) GRCh38

MGI Vertebrate Homology

Adam19 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADAM19
Gene Tree

Adam19

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Phenotype Summary

33 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

139
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

132
Targeted

5
Genomic Mutations

1 involving Adam19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit cardiac developmental defects and die perinatally.

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All GO Annotations

28
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

110
cDNA Data

81
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAM19

Xenbase adam19

ZFIN adam19b

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All Sequences

58
RefSeq

12
UniProt

5
CCDS

CCDS24571.1

Ensembl

ENSMUSG00000011256 (Evidence)
NCBI Gene

11492

			Length	Strain/Species	Flank
genomic	ENSMUSG00000011256	Ensembl Gene Model \| MGI Sequence Detail	91352	C57BL/6J	± kb
transcript	ENSMUST00000011400	Ensembl \| MGI Sequence Detail	6383	Not Applicable
polypeptide	ENSMUSP00000011400	Ensembl \| MGI Sequence Detail	920	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003714 disintegrin and metalloproteinase domain-containing protein 19

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR018358 Disintegrin, conserved site

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR000742 EGF-like domain

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type
GlyGen

O35674 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 87

Genomic 1

cDNA 82

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-33046, MGI:2144353

Summaries

All 76

Developmental Gene Expression 22

Gene Ontology 12

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:355457 Li H, et al., Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model. Lung. 2024 Oct;202(5):659-672

TSS for Adam19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3474	Chr11:45946774-45946794 (+)	-35 bp
Tssr101088	Chr11:45946800-45946895 (+)	29 bp
Tssr101089	Chr11:45946915-45946924 (+)	101 bp
Tssr101090	Chr11:45946992-45947002 (+)	178 bp
Tssr101091	Chr11:45947050-45947057 (+)	235 bp
Tssr101092	Chr11:45951730-45951739 (+)	4,916 bp
Tssr3475	Chr11:45974527-45974543 (+)	27,716 bp
Tssr101093	Chr11:45977492-45977501 (+)	30,678 bp
Tssr101094	Chr11:45977513-45977523 (+)	30,699 bp
Tssr101095	Chr11:46013939-46013958 (+)	67,130 bp
Tssr101096	Chr11:46014443-46014447 (+)	67,626 bp
Tssr101097	Chr11:46015824-46015844 (+)	69,015 bp
Tssr101098	Chr11:46018092-46018096 (+)	71,275 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24