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Sycp1 Gene Detail
Summary
  • Symbol
    Sycp1
  • Name
    synaptonemal complex protein 1
  • Synonyms
    SCP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105931
    NCBI Gene: 20957
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102725815-102843416 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM, cytoband A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1722 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105931
 protein coding gene Chr3:102725815-102843416 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027685
 protein coding gene Chr3:104054531-104180207 (-)
A/J MGP_AJ_G0027644
 protein coding gene Chr3:100752546-100862091 (-)
AKR/J MGP_AKRJ_G0027610
 protein coding gene Chr3:103236855-103351887 (-)
BALB/cJ MGP_BALBcJ_G0027657
 protein coding gene Chr3:100506548-100641538 (-)
C3H/HeJ MGP_C3HHeJ_G0027386
 protein coding gene Chr3:103539365-103670856 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028100
 protein coding gene Chr3:107907328-108049423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025441
 protein coding gene Chr3:96912725-97005060 (-)
CAST/EiJ MGP_CASTEiJ_G0026843
 protein coding gene Chr3:102673538-102781473 (-)
CBA/J MGP_CBAJ_G0027361
 protein coding gene Chr3:111577715-111729272 (-)
DBA/2J MGP_DBA2J_G0027504
 protein coding gene Chr3:100000917-100122399 (-)
FVB/NJ MGP_FVBNJ_G0027472
 protein coding gene Chr3:97935430-98053820 (-)
LP/J MGP_LPJ_G0027611
 protein coding gene Chr3:105396135-105515988 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0028155
 protein coding gene Chr3:102743323-102859523 (-)
PWK/PhJ MGP_PWKPhJ_G0026569
 protein coding gene Chr3:99752771-99859713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026391
 protein coding gene Chr3:100836301-100957239 (-)
WSB/EiJ MGP_WSBEiJ_G0026922
 protein coding gene Chr3:103305890-103429039 (-)



Homology
more
  • Human Ortholog
    SYCP1, synaptonemal complex protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYCP1, synaptonemal complex protein 1
  • Synonyms
    CT8, HOM-TES-14, SCP-1, SCP1
  • Links
    NCBI Gene ID: 6847
    neXtProt AC: NX_Q15431
    UniProt: Q15431

  • Chr Location
    1p13.2; chr1:114854088-114995370 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male and female infertility, azoospermia, small ovary, small testis and seminiferous tubules, absent ovarian follicles, and failure of synapse formation during meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    64
  • cDNA Data
    26
  • Literature Summary
    91
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20957 NCBI Gene Model | MGI Sequence Detail 117602 C57BL/6J ±  kb
    transcript NM_011516 RefSeq | MGI Sequence Detail 3437 C57BL/6  
    polypeptide Q62209 UniProt | EBI | MGI Sequence Detail 993 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 4
      cDNA 27
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33610
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 91
      Diseases 1
      Gene Ontology 39
      Phenotypes 26
    • Earliest
      J:28808 Sage J, et al., cDNA sequence of the murine synaptonemal complex protein 1 (SCP1). Biochim Biophys Acta. 1995 Sep 19;1263(3):258-60
    • Latest
      J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory