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Mki67 Gene Detail
Summary
  • Symbol
    Mki67
  • Name
    antigen identified by monoclonal antibody Ki 67
  • Synonyms
    D630048A14Rik, Ki-67, Ki67
  • Feature Type
    protein coding gene
  • IDs
    MGI:106035
    NCBI Gene: 17345
  • Alliance
    gene page
  • Transcription Start Sites
    74 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:135291513-135318090 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 81.32 cM, cytoband F3-F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    797 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106035
 protein coding gene Chr7:135291513-135318286 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033136
 protein coding gene Chr7:140553479-140581596 (-)
A/J MGP_AJ_G0033118
 protein coding gene Chr7:136621008-136647566 (-)
AKR/J MGP_AKRJ_G0033050
 protein coding gene Chr7:140291437-140329017 (-)
BALB/cJ MGP_BALBcJ_G0033119
 protein coding gene Chr7:136380033-136406667 (-)
C3H/HeJ MGP_C3HHeJ_G0032833
 protein coding gene Chr7:140151747-140180456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033630
 protein coding gene Chr7:145865498-145892056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030603
 protein coding gene Chr7:137855624-137882189 (-)
CAST/EiJ MGP_CASTEiJ_G0032163
 protein coding gene Chr7:132270250-132296844 (-)
CBA/J MGP_CBAJ_G0032806
 protein coding gene Chr7:150759447-150787910 (-)
DBA/2J MGP_DBA2J_G0032958
 protein coding gene Chr7:134629186-134656090 (-)
FVB/NJ MGP_FVBNJ_G0032911
 protein coding gene Chr7:134478779-134505331 (-)
LP/J MGP_LPJ_G0033052
 protein coding gene Chr7:142091130-142118060 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032943
 protein coding gene Chr7:151609603-151641706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033650
 protein coding gene Chr7:139324804-139357704 (-)
PWK/PhJ MGP_PWKPhJ_G0031869
 protein coding gene Chr7:127705518-127737774 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032274
 protein coding gene Chr7:140178239-140207118 (-)



Homology
more
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKI67, marker of proliferation Ki-67
  • Synonyms
    KIA, MIB-, MIB-1, PPP1R105
  • Links
    NCBI Gene ID: 4288
    neXtProt AC: NX_P46013
    UniProt: P46013

  • Chr Location
    10q26.2; chr10:128096659-128126423 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human MKI67 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice carrying a reporter allele show expression in actively dividing cells. Mice homozygous for an endonuclease-mediated hypomorphic allele are resistant to chemical induction of intestinal tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2641
  • Tissues
    791
  • cDNA Data
    341
  • Literature Summary
    2415
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031004 Ensembl Gene Model | MGI Sequence Detail 26578 C57BL/6J ±  kb
transcript ENSMUST00000033310 Ensembl | MGI Sequence Detail 10061 Not Applicable  
polypeptide ENSMUSP00000033310 Ensembl | MGI Sequence Detail 3177 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 355
    Genomic 1
    cDNA 342
    Primer pair 10
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33719, MGI:2444351
References
more
  • Summaries
    All 2513
    Developmental Gene Expression 2415
    Gene Ontology 25
    Phenotypes 41
  • Earliest
    J:31173 Starborg M, et al., The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 1996 Jan;109(Pt 1):143-53
  • Latest
    J:355694 Davidson RK, et al., The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. Diabetologia. 2024 Oct;67(10):2275-2288
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory