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Cyp51 Gene Detail
Summary
  • Symbol
    Cyp51
  • Name
    cytochrome P450, family 51
  • Feature Type
    protein coding gene
  • IDs
    MGI:106040
    NCBI Gene: 13121
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:4131145-4154746 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.30 cM, cytoband A2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    851 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106040
 protein coding gene Chr5:4130674-4154746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029267
 protein coding gene Chr5:906281-931172 (-)
A/J MGP_AJ_G0029231
 protein coding gene Chr5:798732-822404 (-)
AKR/J MGP_AKRJ_G0029181
 protein coding gene Chr5:802469-824466 (-)
BALB/cJ MGP_BALBcJ_G0029249
 protein coding gene Chr5:1007827-1029252 (-)
C3H/HeJ MGP_C3HHeJ_G0028969
 protein coding gene Chr5:1006208-1031578 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029698
 protein coding gene Chr5:1189860-1212437 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026940
 protein coding gene Chr5:805791-831252 (-)
CAST/EiJ MGP_CASTEiJ_G0028382
 protein coding gene Chr5:1012639-1037604 (-)
CBA/J MGP_CBAJ_G0028930
 protein coding gene Chr5:1095482-1124123 (-)
DBA/2J MGP_DBA2J_G0029082
 protein coding gene Chr5:958839-982425 (-)
FVB/NJ MGP_FVBNJ_G0029043
 protein coding gene Chr5:844474-864346 (-)
LP/J MGP_LPJ_G0029172
 protein coding gene Chr5:979496-1001505 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029730
 protein coding gene Chr5:923799-954625 (-)
PWK/PhJ MGP_PWKPhJ_G0028101
 protein coding gene Chr5:914192-936904 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027935
 protein coding gene Chr5:1220386-1241201 (-)
WSB/EiJ MGP_WSBEiJ_G0028462
 protein coding gene Chr5:940011-965845 (-)



Homology
more
  • Human Ortholog
    CYP51A1, cytochrome P450 family 51 subfamily A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP51A1, cytochrome P450 family 51 subfamily A member 1
  • Synonyms
    CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
  • Links
    NCBI Gene ID: 1595
    neXtProt AC: NX_Q16850
    UniProt: Q16850

  • Chr Location
    7q21.2; chr7:92084987-92134803 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 1 allele in 1 genetic background
    4 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit skeletal and craniofacial abnormalities and die at late midgestation due to heart failure resulting from cardiac hypoplasia, ventricle septum, epicardial and vasculogenesis defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1042
  • Tissues
    204
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001467 Ensembl Gene Model | MGI Sequence Detail 23602 C57BL/6J ±  kb
    transcript ENSMUST00000001507 Ensembl | MGI Sequence Detail 3931 Not Applicable  
    polypeptide ENSMUSP00000001507 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 18
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33724, MGI:2140866
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 16
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:35013 Kalb VF, et al., Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae. Gene. 1986;45(3):237-45
    • Latest
      J:316178 Gamart J, et al., SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory