Ptafr MGI Mouse Gene Detail - MGI:106066 - platelet-activating factor receptor

Symbol

Ptafr
Name

platelet-activating factor receptor
Synonyms

PAFR, PAF receptor

Feature Type

protein coding gene
IDs

MGI:106066
NCBI Gene: 19204
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr4:132291378-132309994 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.56 cM, cytoband D2.2
Mapping Data

5 experiments

SNPs within 2kb

744 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106066	protein coding gene	Chr4:132291378-132309994 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028875	protein coding gene	Chr4:134734680-134755175 (+)
A/J	MGP_AJ_G0028834	protein coding gene	Chr4:129127988-129146979 (+)
AKR/J	MGP_AKRJ_G0028787	protein coding gene	Chr4:132763122-132782949 (+)
BALB/cJ	MGP_BALBcJ_G0028857	protein coding gene	Chr4:129747986-129767693 (+)
C3H/HeJ	MGP_C3HHeJ_G0028571	protein coding gene	Chr4:133030126-133048383 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029299	protein coding gene	Chr4:139603110-139623059 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026570	protein coding gene	Chr4:122205731-122222034 (+)
CAST/EiJ	MGP_CASTEiJ_G0028004	protein coding gene	Chr4:131105024-131125174 (+)
CBA/J	MGP_CBAJ_G0028537	protein coding gene	Chr4:143173461-143196549 (+)
DBA/2J	MGP_DBA2J_G0028686	protein coding gene	Chr4:129549021-129568057 (+)
FVB/NJ	MGP_FVBNJ_G0028653	protein coding gene	Chr4:128404713-128425950 (+)
LP/J	MGP_LPJ_G0028787	protein coding gene	Chr4:134887245-134908284 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028679	protein coding gene	Chr4:147764204-147788849 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029337	protein coding gene	Chr4:133179595-133202709 (+)
PWK/PhJ	MGP_PWKPhJ_G0027725	protein coding gene	Chr4:126243690-126262371 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027551	protein coding gene	Chr4:129024599-129044867 (+)
WSB/EiJ	MGP_WSBEiJ_G0028084	protein coding gene	Chr4:133351346-133370971 (+)

Human Ortholog

PTAFR, platelet activating factor receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTAFR, platelet activating factor receptor
Synonyms

PAFR
Links

HGNC:9582

NCBI Gene ID: 5724

neXtProt AC: NX_P25105

UniProt: P25105
Chr Location

1p35.3; chr1:28147166-28193936 (-) GRCh38

MGI Vertebrate Homology

Ptafr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTAFR
Gene Tree

Ptafr

less

Phenotype Summary

10 phenotypes from 3 alleles in 4 genetic backgrounds
84 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Ptafr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection.

less

All GO Annotations

60
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

9
cDNA Data

8
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptafr

less

All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS38899.1

Ensembl

ENSMUSG00000056529 (Evidence)
NCBI Gene

19204

			Length	Strain/Species	Flank
genomic	19204	NCBI Gene Model \| MGI Sequence Detail	18617	C57BL/6J	± kb
transcript	NM_001081211	RefSeq \| MGI Sequence Detail	3519	C57BL/6
polypeptide	Q62035	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000001501 mammalian-type platelet-activating factor receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR002282 Platelet-activating factor receptor
GlyGen

Q62035 2 sites

less

All nucleic 12

Genomic 1

cDNA 8

Primer pair 3

Microarray probesets 6

less

MGD-MRK-33750

Summaries

All 127

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 84
Earliest

J:31955 Ishii S, et al., A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem J. 1996 Mar 1;314(Pt 2):671-8
Latest

J:358084 Suzuki T, et al., Re-evaluation of the canonical PAF pathway in cutaneous anaphylaxis. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Sep 25;1870(1):159563

TSS for Ptafr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39381	Chr4:132290764-132290792 (+)	-600 bp
Tssr39382	Chr4:132290802-132290821 (+)	-566 bp
Tssr39383	Chr4:132290881-132290904 (+)	-485 bp
Tssr39384	Chr4:132290910-132290939 (+)	-453 bp
Tssr39385	Chr4:132291029-132291048 (+)	-339 bp
Tssr39386	Chr4:132291362-132291387 (+)	-3 bp
Tssr39387	Chr4:132291393-132291404 (+)	21 bp
Tssr39388	Chr4:132291494-132291521 (+)	130 bp
Tssr39389	Chr4:132292671-132292679 (+)	1,297 bp
Tssr39390	Chr4:132295633-132295678 (+)	4,278 bp
Tssr39391	Chr4:132295720-132295744 (+)	4,354 bp
Tssr39392	Chr4:132295808-132295819 (+)	4,436 bp
Tssr39393	Chr4:132295889-132295904 (+)	4,519 bp
Tssr39394	Chr4:132295916-132295967 (+)	4,564 bp
Tssr39395	Chr4:132295971-132296005 (+)	4,610 bp
Tssr39396	Chr4:132296124-132296135 (+)	4,752 bp
Tssr39397	Chr4:132306721-132306738 (+)	15,352 bp
Tssr39398	Chr4:132306847-132306874 (+)	15,483 bp
Tssr39399	Chr4:132307968-132307988 (+)	16,600 bp
Tssr39400	Chr4:132308429-132308440 (+)	17,057 bp
Tssr39401	Chr4:132308455-132308476 (+)	17,088 bp
Tssr39402	Chr4:132308495-132308515 (+)	17,127 bp
Tssr39403	Chr4:132308794-132308822 (+)	17,430 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24