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Cyp7a1 Gene Detail
Summary
  • Symbol
    Cyp7a1
  • Name
    cytochrome P450, family 7, subfamily a, polypeptide 1
  • Synonyms
    cholesterol 7 alpha hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:106091
    NCBI Gene: 13122
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:6265612-6275632 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106091
 protein coding gene Chr4:6265612-6275633 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028034
 protein coding gene Chr4:2775522-2785770 (-)
A/J MGP_AJ_G0027992
 protein coding gene Chr4:2798316-2808509 (-)
AKR/J MGP_AKRJ_G0027958
 protein coding gene Chr4:2784800-2795006 (-)
BALB/cJ MGP_BALBcJ_G0028004
 protein coding gene Chr4:2752400-2762589 (-)
C3H/HeJ MGP_C3HHeJ_G0027734
 protein coding gene Chr4:2922403-2932424 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028447
 protein coding gene Chr4:3007006-3017027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025791
 protein coding gene Chr4:2541385-2551952 (-)
CAST/EiJ MGP_CASTEiJ_G0027187
 protein coding gene Chr4:2788386-2798443 (-)
CBA/J MGP_CBAJ_G0027709
 protein coding gene Chr4:3004991-3015012 (-)
DBA/2J MGP_DBA2J_G0027849
 protein coding gene Chr4:2758877-2769445 (-)
FVB/NJ MGP_FVBNJ_G0027816
 protein coding gene Chr4:2648652-2658844 (-)
LP/J MGP_LPJ_G0027960
 protein coding gene Chr4:2826746-2836862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027849
 protein coding gene Chr4:3212596-3225115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028506
 protein coding gene Chr4:2780584-2790605 (-)
PWK/PhJ MGP_PWKPhJ_G0026909
 protein coding gene Chr4:2798660-2812580 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026739
 protein coding gene Chr4:2730490-2740585 (-)
WSB/EiJ MGP_WSBEiJ_G0027267
 protein coding gene Chr4:2893232-2903295 (-)



Homology
more
  • Human Ortholog
    CYP7A1, cytochrome P450 family 7 subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP7A1, cytochrome P450 family 7 subfamily A member 1
  • Synonyms
    CP7A, CYP7, CYPVII
  • Links
    NCBI Gene ID: 1581
    neXtProt AC: NX_P22680
    UniProt: P22680

  • Chr Location
    8q12.1; chr8:58490178-58500163 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene experience severe neonatal and postnatal lethality. Supplementation of the maternal diet with fat soluble vitamins and cholic acid starting before birth alleviates much of the phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    2
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13122 NCBI Gene Model | MGI Sequence Detail 10021 C57BL/6J ±  kb
    transcript NM_007824 RefSeq | MGI Sequence Detail 4173 C57BL/6  
    polypeptide Q64505 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 18
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33776
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 13
      Gene Ontology 14
      Phenotypes 25
    • Earliest
      J:18307 Tzung KW, et al., Structure of the mouse cholesterol 7 alpha-hydroxylase gene. Genomics. 1994 May 1;21(1):244-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory