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Etfa Gene Detail
Summary
  • Symbol
    Etfa
  • Name
    electron transferring flavoprotein, alpha polypeptide
  • Synonyms
    2010200I21Rik, D9Ertd394e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106092
    NCBI Gene: 110842
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:55361792-55419527 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.13 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1125 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106092
 protein coding gene Chr9:55361720-55419528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034842
 protein coding gene Chr9:54562680-54629158 (-)
A/J MGP_AJ_G0034823
 protein coding gene Chr9:52795529-52855663 (-)
AKR/J MGP_AKRJ_G0034752
 protein coding gene Chr9:54005203-54066729 (-)
BALB/cJ MGP_BALBcJ_G0034815
 protein coding gene Chr9:52571265-52634830 (-)
C3H/HeJ MGP_C3HHeJ_G0034525
 protein coding gene Chr9:54469708-54529384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035334
 protein coding gene Chr9:56068988-56130100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032246
 protein coding gene Chr9:52198004-52259399 (-)
CAST/EiJ MGP_CASTEiJ_G0033846
 protein coding gene Chr9:54499410-54561507 (-)
CBA/J MGP_CBAJ_G0034496
 protein coding gene Chr9:58022423-58088882 (-)
DBA/2J MGP_DBA2J_G0034655
 protein coding gene Chr9:52687380-52745770 (-)
FVB/NJ MGP_FVBNJ_G0034597
 protein coding gene Chr9:51891954-51950801 (-)
LP/J MGP_LPJ_G0034738
 protein coding gene Chr9:54859118-54920596 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034640
 protein coding gene Chr9:59530351-59591055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035356
 protein coding gene Chr9:54022597-54080994 (-)
PWK/PhJ MGP_PWKPhJ_G0033551
 protein coding gene Chr9:52681136-52740051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033386
 protein coding gene Chr9:54295085-54358873 (-)
WSB/EiJ MGP_WSBEiJ_G0033959
 protein coding gene Chr9:53983681-54043456 (-)



Homology
more
  • Human Ortholog
    ETFA, electron transfer flavoprotein subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ETFA, electron transfer flavoprotein subunit alpha
  • Synonyms
    EMA, GA2, MADD
  • Links
    NCBI Gene ID: 2108
    neXtProt AC: NX_P13804
    UniProt: P13804

  • Chr Location
    15q24.2-q24.3; chr15:76188555-76311730 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ETFA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    98
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032314 Ensembl Gene Model | MGI Sequence Detail 57736 C57BL/6J ±  kb
    transcript ENSMUST00000034866 Ensembl | MGI Sequence Detail 1392 Not Applicable  
    polypeptide ENSMUSP00000034866 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007215 electron transfer flavoprotein subunit alpha, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR029035 DHS-like NAD/FAD-binding domain superfamily
      IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
      IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal
      IPR001308 Electron transfer flavoprotein alpha subunit/FixB
      IPR033947 Electron transfer flavoprotein, alpha subunit, N-terminal
      IPR018206 Electron transfer flavoprotein subunit alpha, conserved site
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    • GlyGen
      Q99LC5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33778, MGI:1196445, MGI:2444349
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:320288 Finocchiaro G, et al., cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Eur J Biochem. 1993 May 1;213(3):1003-8
    • Latest
      J:345334 Xie H, et al., SUMOylation of ERp44 enhances Ero1alpha ER retention contributing to the pathogenesis of obesity and insulin resistance. Metabolism. 2023 Feb;139:155351
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory