Ocln MGI Mouse Gene Detail - MGI:106183

Symbol

Ocln
Name

occludin
Synonyms

Ocl

Feature Type

protein coding gene
IDs

MGI:106183
NCBI Gene: 18260
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:100633015-100689226 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 53.23 cM
Mapping Data

5 experiments

SNPs within 2kb

1682 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106183	protein coding gene	Chr13:100633012-100689226 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020886	protein coding gene	Chr13:102418803-102473949 (-)
A/J	MGP_AJ_G0020838	protein coding gene	Chr13:98436688-98493745 (-)
AKR/J	MGP_AKRJ_G0020813	protein coding gene	Chr13:101465520-101521572 (-)
BALB/cJ	MGP_BALBcJ_G0020837	protein coding gene	Chr13:99169291-99222755 (-)
C3H/HeJ	MGP_C3HHeJ_G0020627	protein coding gene	Chr13:101176086-101229607 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021271	protein coding gene	Chr13:105464277-105520332 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018842	protein coding gene	Chr13:94272039-94325163 (-)
CAST/EiJ	MGP_CASTEiJ_G0020146	protein coding gene	Chr13:100620555-100686208 (-)
CBA/J	MGP_CBAJ_G0020588	protein coding gene	Chr13:109623219-109686596 (-)
DBA/2J	MGP_DBA2J_G0020713	protein coding gene	Chr13:98223516-98279450 (-)
FVB/NJ	MGP_FVBNJ_G0020694	protein coding gene	Chr13:96963905-97017384 (-)
LP/J	MGP_LPJ_G0020787	protein coding gene	Chr13:102441528-102495344 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020723	protein coding gene	Chr13:109887009-109943548 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021311	protein coding gene	Chr13:100911579-100972515 (-)
PWK/PhJ	MGP_PWKPhJ_G0019899	protein coding gene	Chr13:96934543-96993116 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019721	protein coding gene	Chr13:97142654-97200883 (-)
WSB/EiJ	MGP_WSBEiJ_G0020203	protein coding gene	Chr13:101376472-101434899 (-)

Human Ortholog

OCLN, occludin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OCLN, occludin
Synonyms

BLCPMG, PPP1R115, PTORCH1
Links

HGNC:8104

NCBI Gene ID: 100506658

neXtProt AC: NX_Q16625

UniProt: Q16625
Chr Location

5

MGI Vertebrate Homology

Ocln stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OCLN
Protein SuperFamily

Occludin
Gene Tree

Ocln

Diseases

2 with human OCLN associations

				Human Disease	Mouse Models
				Crohn's disease IDs Crohn's disease DOID:8778 DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C37262 UMLS_CUI:C0156147
				pseudo-TORCH syndrome 1 IDs pseudo-TORCH syndrome 1 DOID:0050656 OMIM:251290 ORDO:1229

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 5 alleles in 4 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

3
Targeted

7
Transgenic

2
Genomic Mutations

1 involving Ocln
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.

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All GO Annotations

45
GO References

28

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

980
Tissues

187
cDNA Data

12
Literature Summary

108

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ocln

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All Sequences

56
RefSeq

10
UniProt

5
CCDS

CCDS26731.1

Ensembl

ENSMUSG00000021638 (Evidence)
NCBI Gene

18260

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021638	Ensembl Gene Model \| MGI Sequence Detail	56212	C57BL/6J	± kb
transcript	ENSMUST00000069756	Ensembl \| MGI Sequence Detail	4052	Not Applicable
polypeptide	ENSMUSP00000065284	Ensembl \| MGI Sequence Detail	521	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000002207 occludin

(term hierarchy)
InterPro Domains

IPR031176 ELL/occludin family

IPR008253 Marvel domain

IPR002958 Occludin

IPR010844 Occludin homology domain

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All nucleic 27

Genomic 8

cDNA 12

Primer pair 7

Microarray probesets 6

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MGD-MRK-33873, MGI:2145262

Summaries

All 210

Developmental Gene Expression 108

Diseases 1

Gene Ontology 28

Phenotypes 34
Earliest

J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
Latest

J:358278 Yang Y, et al., Erythrocytic alpha-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2024 Jan;39(1):40-52

TSS for Ocln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123798	Chr13:100689675-100689718 (-)	-471 bp
Tssr123797	Chr13:100689212-100689229 (-)	5 bp
Tssr123796	Chr13:100689174-100689185 (-)	46 bp
Tssr123795	Chr13:100689106-100689164 (-)	91 bp
Tssr123794	Chr13:100688950-100688987 (-)	257 bp
Tssr123793	Chr13:100651643-100651647 (-)	37,581 bp
Tssr123792	Chr13:100634405-100634407 (-)	54,820 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24