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Skil Gene Detail
Summary
  • Symbol
    Skil
  • Name
    SKI-like
  • Synonyms
    9130011J04Rik, Skir, sno-dE3, SnoN, SnoN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106203
    NCBI Gene: 20482
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31149259-31176741 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106203
 protein coding gene Chr3:31149207-31176741 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027131
 protein coding gene Chr3:28616118-28645089 (+)
A/J MGP_AJ_G0027091
 protein coding gene Chr3:28243487-28271350 (+)
AKR/J MGP_AKRJ_G0027060
 protein coding gene Chr3:28673908-28701426 (+)
BALB/cJ MGP_BALBcJ_G0027103
 protein coding gene Chr3:27925748-27953250 (+)
C3H/HeJ MGP_C3HHeJ_G0026845
 protein coding gene Chr3:28687905-28717443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027549
 protein coding gene Chr3:30129812-30158626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024910
 protein coding gene Chr3:26143411-26171389 (+)
CAST/EiJ MGP_CASTEiJ_G0026299
 protein coding gene Chr3:28617837-28646651 (+)
CBA/J MGP_CBAJ_G0026823
 protein coding gene Chr3:30895154-30927111 (+)
DBA/2J MGP_DBA2J_G0026957
 protein coding gene Chr3:27789585-27817591 (+)
FVB/NJ MGP_FVBNJ_G0026925
 protein coding gene Chr3:27232973-27260459 (+)
LP/J MGP_LPJ_G0027068
 protein coding gene Chr3:29316127-29345469 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026945
 protein coding gene Chr3:33473658-33502270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027608
 protein coding gene Chr3:28456134-28485049 (+)
PWK/PhJ MGP_PWKPhJ_G0026032
 protein coding gene Chr3:27306304-27331877 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025844
 protein coding gene Chr3:27943654-27971104 (+)
WSB/EiJ MGP_WSBEiJ_G0026373
 protein coding gene Chr3:28517164-28545663 (+)



Homology
more
  • Human Ortholog
    SKIL, SKI like proto-oncogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKIL, SKI like proto-oncogene
  • Synonyms
    SNO, SnoA, SnoI, SnoN
  • Links
    NCBI Gene ID: 6498
    neXtProt AC: NX_P12757
    UniProt: P12757

  • Chr Location
    3q26.2; chr3:170357342-170396849 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygotes for a null allele develop lymphomas and show increased incidence of chemically-induced tumors while homozygotes die before implantation. Homozygotes for a different null allele are viable but show defective T cell activation and impaired mammary gland alveologenesis and lactogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    150
  • cDNA Data
    23
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20482 NCBI Gene Model | MGI Sequence Detail 27483 C57BL/6J ±  kb
    transcript NM_011386 RefSeq | MGI Sequence Detail 6683 C57BL/6  
    polypeptide Q60665 UniProt | EBI | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 3
      cDNA 25
      Primer pair 4
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33894, MGI:1918865
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:28741 Pearson-White S, et al., The ski/sno protooncogene family in hematopoietic development. Blood. 1995 Sep 15;86(6):2146-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory