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Nrp1 Gene Detail
Summary
  • Symbol
    Nrp1
  • Name
    neuropilin 1
  • Synonyms
    Neuropilin-1, NP-1, Npn1, NPN-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106206
    NCBI Gene: 18186
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:129085085-129229844 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 75.78 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2720 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106206
 protein coding gene Chr8:129085085-129231957 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034300
 protein coding gene Chr8:132303633-132466759 (+)
A/J MGP_AJ_G0034279
 protein coding gene Chr8:126832753-126980378 (+)
AKR/J MGP_AKRJ_G0034206
 protein coding gene Chr8:130485076-130638031 (+)
BALB/cJ MGP_BALBcJ_G0034272
 protein coding gene Chr8:126983940-127131539 (+)
C3H/HeJ MGP_C3HHeJ_G0033983
 protein coding gene Chr8:131105076-131258539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034792
 protein coding gene Chr8:136586172-136742155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031734
 protein coding gene Chr8:119462446-119610187 (+)
CAST/EiJ MGP_CASTEiJ_G0033310
 protein coding gene Chr8:131310436-131473318 (+)
CBA/J MGP_CBAJ_G0033957
 protein coding gene Chr8:141722781-141882852 (+)
DBA/2J MGP_DBA2J_G0034112
 protein coding gene Chr8:125903220-126049421 (+)
FVB/NJ MGP_FVBNJ_G0034057
 protein coding gene Chr8:125139758-125286670 (+)
LP/J MGP_LPJ_G0034201
 protein coding gene Chr8:132479687-132639622 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034103
 protein coding gene Chr8:143575840-143736216 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034811
 protein coding gene Chr8:130697735-130849659 (+)
PWK/PhJ MGP_PWKPhJ_G0033013
 protein coding gene Chr8:125736629-125891093 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032851
 protein coding gene Chr8:129385558-129538837 (+)
WSB/EiJ MGP_WSBEiJ_G0033428
 protein coding gene Chr8:131457125-131607922 (+)



Homology
more
  • Human Ortholog
    NRP1, neuropilin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRP1, neuropilin 1
  • Synonyms
    BDCA4, CD304, NP1, NRP, VEGF165R
  • Links
    NCBI Gene ID: 8829
    neXtProt AC: NX_O14786
    UniProt: O14786

  • Chr Location
    10p11.22; chr10:33177492-33336262 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrp1 mouse models; 2 with human NRP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 7 alleles in 12 genetic backgrounds
    11 phenotypes from multigenic genotypes
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show embryonic death, impaired neuronal migration and axon guidance, and vascular defects including a disorganized yolk sac vascular plexus, and malformed brachial arch arteries and great vessels. Mice lacking the cytoplasmic domain show altered retinal arteriovenous patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    182
  • GO References
    43
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1332
  • Tissues
    351
  • cDNA Data
    27
  • Literature Summary
    294
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025810 Ensembl Gene Model | MGI Sequence Detail 144760 C57BL/6J ±  kb
    transcript ENSMUST00000026917 Ensembl | MGI Sequence Detail 3597 Not Applicable  
    polypeptide ENSMUSP00000026917 Ensembl | MGI Sequence Detail 923 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 2
      cDNA 34
      Primer pair 13
      Other 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33897
    References
    more
    • Summaries
      All 482
      Developmental Gene Expression 294
      Diseases 1
      Gene Ontology 43
      Phenotypes 159
    • Earliest
      J:30346 Kitsukawa T, et al., Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development. 1995 Dec;121(12):4309-18
    • Latest
      J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory