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Cdc42 Gene Detail
Summary
  • Symbol
    Cdc42
  • Name
    cell division cycle 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:106211
    NCBI Gene: 12540
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137047011-137085007 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.83 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106211
 protein coding gene Chr4:137047007-137085031 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028979
 protein coding gene Chr4:139933645-139972589 (-)
A/J MGP_AJ_G0028938
 protein coding gene Chr4:133986368-134025106 (-)
AKR/J MGP_AKRJ_G0028890
 protein coding gene Chr4:137842675-137880521 (-)
BALB/cJ MGP_BALBcJ_G0028962
 protein coding gene Chr4:134649220-134687319 (-)
C3H/HeJ MGP_C3HHeJ_G0028676
 protein coding gene Chr4:138134614-138175850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029403
 protein coding gene Chr4:144899954-144941504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026674
 protein coding gene Chr4:127007991-127043364 (-)
CAST/EiJ MGP_CASTEiJ_G0028108
 protein coding gene Chr4:136288895-136333405 (-)
CBA/J MGP_CBAJ_G0028641
 protein coding gene Chr4:148941271-148987330 (-)
DBA/2J MGP_DBA2J_G0028790
 protein coding gene Chr4:134382887-134421389 (-)
FVB/NJ MGP_FVBNJ_G0028757
 protein coding gene Chr4:133354808-133393068 (-)
LP/J MGP_LPJ_G0028889
 protein coding gene Chr4:140020769-140059831 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028783
 protein coding gene Chr4:153051353-153093656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029441
 protein coding gene Chr4:138314605-138353651 (-)
PWK/PhJ MGP_PWKPhJ_G0027828
 protein coding gene Chr4:131190004-131230031 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027654
 protein coding gene Chr4:134120989-134162390 (-)
WSB/EiJ MGP_WSBEiJ_G0028186
 protein coding gene Chr4:138485029-138524831 (-)



Homology
more
  • Human Ortholog
    CDC42, cell division cycle 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC42, cell division cycle 42
  • Synonyms
    CDC42Hs, G25K, TKS
  • Links
    NCBI Gene ID: 998
    neXtProt AC: NX_P60953
    UniProt: P60953

  • Chr Location
    1p36.12; chr1:22052627-22101360 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cdc42 mouse models; 1 with human CDC42 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    153 phenotypes from 8 alleles in 14 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    204
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1111
  • Tissues
    243
  • cDNA Data
    52
  • Literature Summary
    91
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12540 NCBI Gene Model | MGI Sequence Detail 37997 C57BL/6J ±  kb
    transcript NR_185140 RefSeq | MGI Sequence Detail 4358 ZRU/MplStud  
    polypeptide P60766 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 52
      Primer pair 10
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33903, MGI:2140354, MGI:2140443
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 91
      Diseases 2
      Gene Ontology 53
      Phenotypes 132
    • Earliest
      J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39(1):279-84
    • Latest
      J:353687 Zhao R, et al., Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis. Cell Stem Cell. 2024 Jul 27;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory