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Capza2 Gene Detail
Summary
  • Symbol
    Capza2
  • Name
    capping actin protein of muscle Z-line subunit alpha 2
  • Synonyms
    1110053K06Rik, Cappa2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106222
    NCBI Gene: 12343
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:17637009-17666971 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 7.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    772 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106222
 protein coding gene Chr6:17636233-17666971 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030471
 protein coding gene Chr6:14894323-14925046 (+)
A/J MGP_AJ_G0030444
 protein coding gene Chr6:14285711-14317206 (+)
AKR/J MGP_AKRJ_G0030371
 protein coding gene Chr6:14781868-14812644 (+)
BALB/cJ MGP_BALBcJ_G0030453
 protein coding gene Chr6:14375531-14406349 (+)
C3H/HeJ MGP_C3HHeJ_G0030167
 protein coding gene Chr6:14651263-14681654 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030908
 protein coding gene Chr6:15353716-15384199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028119
 protein coding gene Chr6:13248832-13278798 (+)
CAST/EiJ MGP_CASTEiJ_G0029569
 protein coding gene Chr6:14559335-14593000 (+)
CBA/J MGP_CBAJ_G0030145
 protein coding gene Chr6:15857790-15890495 (+)
DBA/2J MGP_DBA2J_G0030289
 protein coding gene Chr6:14219529-14250447 (+)
FVB/NJ MGP_FVBNJ_G0030243
 protein coding gene Chr6:14053962-14084815 (+)
LP/J MGP_LPJ_G0030376
 protein coding gene Chr6:14977776-15011501 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030279
 protein coding gene Chr6:17035871-17067323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030938
 protein coding gene Chr6:14668451-14700401 (+)
PWK/PhJ MGP_PWKPhJ_G0029283
 protein coding gene Chr6:13867521-13898762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029119
 protein coding gene Chr6:14547639-14578183 (+)
WSB/EiJ MGP_WSBEiJ_G0029645
 protein coding gene Chr6:14608321-14640291 (+)



Homology
more
  • Human Ortholog
    CAPZA2, capping actin protein of muscle Z-line subunit alpha 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPZA2, capping actin protein of muscle Z-line subunit alpha 2
  • Synonyms
    CAPPA2, CAPZ
  • Links
    NCBI Gene ID: 830
    neXtProt AC: NX_P47755
    UniProt: P47755

  • Chr Location
    7q31.2; chr7:116811070-116922049 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    9
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12343 NCBI Gene Model | MGI Sequence Detail 29963 C57BL/6J ±  kb
    transcript NM_007604 RefSeq | MGI Sequence Detail 2541 ZRU/MplStud  
    polypeptide P47754 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005030 F-actin-capping protein subunit alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR017865 F-actin capping protein, alpha subunit, conserved site
      IPR042489 F-actin capping protein, alpha subunit, domain 1
      IPR002189 F-actin-capping protein subunit alpha
      IPR037282 F-actin-capping protein subunit alpha/beta
      IPR042276 F-actin-capping protein subunit alpha/beta, domain 2
    • GlyGen
      P47754 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33914, MGI:1924163, MGI:2141661
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:37796 Hart MC, et al., Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. Genomics. 1997 Feb 1;39(3):264-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory