Capza1 MGI Mouse Gene Detail - MGI:106227 - capping actin protein of muscle Z-line subunit alpha 1

Symbol

Capza1
Name

capping actin protein of muscle Z-line subunit alpha 1
Synonyms

Cappa1

Feature Type

protein coding gene
IDs

MGI:106227
NCBI Gene: 12340
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:104730097-104771821 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.88 cM
Mapping Data

1 experiment

SNPs within 2kb

903 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106227	protein coding gene	Chr3:104730095-104771821 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027712	protein coding gene	Chr3:106143592-106191915 (-)
A/J	MGP_AJ_G0027672	protein coding gene	Chr3:102762951-102806070 (-)
AKR/J	MGP_AKRJ_G0027637	protein coding gene	Chr3:105290094-105338906 (-)
BALB/cJ	MGP_BALBcJ_G0027684	protein coding gene	Chr3:102549344-102591683 (-)
C3H/HeJ	MGP_C3HHeJ_G0027414	protein coding gene	Chr3:105672335-105714787 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028128	protein coding gene	Chr3:110113260-110155414 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025468	protein coding gene	Chr3:98872381-98913697 (-)
CAST/EiJ	MGP_CASTEiJ_G0026870	protein coding gene	Chr3:104787563-104830782 (-)
CBA/J	MGP_CBAJ_G0027389	protein coding gene	Chr3:113868474-113909465 (-)
DBA/2J	MGP_DBA2J_G0027531	protein coding gene	Chr3:102017521-102059341 (-)
FVB/NJ	MGP_FVBNJ_G0027499	protein coding gene	Chr3:99939225-99982687 (-)
LP/J	MGP_LPJ_G0027638	protein coding gene	Chr3:107526382-107579435 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027529	protein coding gene	Chr3:119983023-120031764 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028183	protein coding gene	Chr3:104848555-104891852 (-)
PWK/PhJ	MGP_PWKPhJ_G0026596	protein coding gene	Chr3:101792391-101834814 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026417	protein coding gene	Chr3:102891636-102933703 (-)
WSB/EiJ	MGP_WSBEiJ_G0026950	protein coding gene	Chr3:105428328-105475252 (-)

Human Ortholog

CAPZA1, capping actin protein of muscle Z-line subunit alpha 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPZA1, capping actin protein of muscle Z-line subunit alpha 1
Synonyms

CAPPA1, CAPZ, CAZ1
Links

HGNC:1488

NCBI Gene ID: 829

neXtProt AC: NX_P52907

UniProt: P52907
Chr Location

1p13.2; chr1:112619805-112671616 (+) GRCh38

MGI Vertebrate Homology

Capza1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CAPZA1
Gene Tree

Capza1

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

29
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Capza1
Incidental Mutations

CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

5
cDNA Data

178
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase capza1

ZFIN capza1a, capza1b

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All Sequences

58
RefSeq

4
UniProt

7
CCDS

CCDS38580.1

Ensembl

ENSMUSG00000070372 (Evidence)
NCBI Gene

12340

			Length	Strain/Species	Flank
genomic	12340	NCBI Gene Model \| MGI Sequence Detail	41725	C57BL/6J	± kb
transcript	NM_009797	RefSeq \| MGI Sequence Detail	3191	ZRU/MplStud
polypeptide	P47753	UniProt \| EBI \| MGI Sequence Detail	286	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005029 F-actin-capping protein subunit alpha-1

(term hierarchy)
PDB

7CCC, 7PDZ, 8P94
InterPro Domains

IPR017865 F-actin capping protein, alpha subunit, conserved site

IPR042489 F-actin capping protein, alpha subunit, domain 1

IPR002189 F-actin-capping protein subunit alpha

IPR037282 F-actin-capping protein subunit alpha/beta

IPR042276 F-actin-capping protein subunit alpha/beta, domain 2

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All nucleic 180

Genomic 1

cDNA 178

Primer pair 1

Microarray probesets 5

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MGD-MRK-33919

Summaries

All 47

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:37796 Hart MC, et al., Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes. Genomics. 1997 Feb 1;39(3):264-70
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Capza1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34907	Chr3:104772404-104772433 (-)	-598 bp
Tssr34906	Chr3:104772280-104772361 (-)	-500 bp
Tssr34905	Chr3:104771736-104771766 (-)	70 bp
Tssr34904	Chr3:104771184-104771187 (-)	635 bp
Tssr34903	Chr3:104771134-104771144 (-)	682 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24