About   Help   FAQ
Eif5a Gene Detail
Summary
  • Symbol
    Eif5a
  • Name
    eukaryotic translation initiation factor 5A
  • Synonyms
    D19Wsu54e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106248
    NCBI Gene: 276770
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69807540-69812784 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106248
 protein coding gene Chr11:69807538-69812784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018569
 protein coding gene Chr11:70403652-70408904 (-)
A/J MGP_AJ_G0018537
 protein coding gene Chr11:67738389-67743050 (-)
AKR/J MGP_AKRJ_G0018506
 protein coding gene Chr11:69760746-69765289 (-)
BALB/cJ MGP_BALBcJ_G0018509
 protein coding gene Chr11:68070900-68075046 (-)
C3H/HeJ MGP_C3HHeJ_G0018322
 protein coding gene Chr11:69797306-69801846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018960
 protein coding gene Chr11:72529583-72534341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016605
 protein coding gene Chr11:64665441-64669527 (-)
CAST/EiJ MGP_CASTEiJ_G0017877
 protein coding gene Chr11:70038035-70042060 (-)
CBA/J MGP_CBAJ_G0018294
 protein coding gene Chr11:75778897-75783447 (-)
DBA/2J MGP_DBA2J_G0018404
 protein coding gene Chr11:67324879-67328992 (-)
FVB/NJ MGP_FVBNJ_G0018394
 protein coding gene Chr11:66965582-66970829 (-)
LP/J MGP_LPJ_G0018474
 protein coding gene Chr11:70986415-70991671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018417
 protein coding gene Chr11:76373144-76380210 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019002
 protein coding gene Chr11:70032836-70037082 (-)
PWK/PhJ MGP_PWKPhJ_G0017651
 protein coding gene Chr11:67975373-67979828 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017441
 protein coding gene Chr11:69841006-69845073 (-)
WSB/EiJ MGP_WSBEiJ_G0017931
 protein coding gene Chr11:69695313-69699629 (-)



Homology
more
  • Human Ortholog
    EIF5A, eukaryotic translation initiation factor 5A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF5A, eukaryotic translation initiation factor 5A
  • Synonyms
    eIF-4D, EIF-5A, EIF5A1, eIF5AI, FABAS
  • Links
    NCBI Gene ID: 1984
    neXtProt AC: NX_P63241
    UniProt: P63241

  • Chr Location
    17p13.1; chr17:7306999-7312463 (+)  GRCh38
  • Human Ortholog
    EIF5AL1, eukaryotic translation initiation factor 5A like 1
  • Synonyms
    bA342M3.3, eIF-4D, eIF-5A, EIF5A, eIF-5A-1, eIF-5A1, EIF5AP1
  • Links
    NCBI Gene ID: 143244
    neXtProt AC: NX_Q6IS14
    UniProt: Q6IS14

  • Chr Location
    10q22.3; chr10:79512533-79516440 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display lethality prior to somite formation and reduced blastocyst cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    29
  • cDNA Data
    14
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078812 Ensembl Gene Model | MGI Sequence Detail 5245 C57BL/6J ±  kb
transcript ENSMUST00000108613 Ensembl | MGI Sequence Detail 1343 Not Applicable  
polypeptide ENSMUSP00000104253 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007003 eukaryotic translation initiation factor 5A-1
    (term hierarchy)
  • InterPro Domains
    IPR014722 Large ribosomal subunit protein uL2, domain 2
    IPR012340 Nucleic acid-binding, OB-fold
    IPR020189 Translation elongation factor, IF5A C-terminal
    IPR019769 Translation elongation factor, IF5A, hypusine site
    IPR001884 Translation elongation factor IF5A-like
    IPR048670 Translation initiation factor 5A-like, N-terminal
    IPR008991 Translation protein SH3-like domain superfamily
  • GlyGen
    P63242 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33940, MGI:2145157
References
more
  • Summaries
    All 64
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:335172 Schultz CR, et al., New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Biol Open. 2023 Mar 15;12(3)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory