Desi1 MGI Mouse Gene Detail - MGI:106313 - desumoylating isopeptidase 1

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Desi1 Gene Detail

Symbol

Desi1
Name

desumoylating isopeptidase 1
Synonyms

D15Wsu75e, Fam152b, Pppde2

Feature Type

protein coding gene
IDs

MGI:106313
NCBI Gene: 28075
Alliance

gene page
Transcription Start Sites

4 TSS
Candidate for QTL

4 QTL

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Sequence Map

Chr15:81876724-81900364 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.34 cM
Mapping Data

5 experiments

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SNPs within 2kb

692 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_106313	protein coding gene	Chr15:81876724-81918063 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022130	protein coding gene	Chr15:82473423-82517042 (-)
A/J	MGP_AJ_G0022091	protein coding gene	Chr15:79557432-79598504 (-)
AKR/J	MGP_AKRJ_G0022066	protein coding gene	Chr15:81756483-81797488 (-)
BALB/cJ	MGP_BALBcJ_G0022096	protein coding gene	Chr15:79603367-79644675 (-)
C3H/HeJ	MGP_C3HHeJ_G0021867	protein coding gene	Chr15:81776937-81818821 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022539	protein coding gene	Chr15:85709600-85751044 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020068	protein coding gene	Chr15:75998816-76040734 (-)
CAST/EiJ	MGP_CASTEiJ_G0021387	protein coding gene	Chr15:82565927-82612733 (-)
CBA/J	MGP_CBAJ_G0021832	protein coding gene	Chr15:88381982-88422964 (-)
DBA/2J	MGP_DBA2J_G0021961	protein coding gene	Chr15:79030074-79071273 (-)
FVB/NJ	MGP_FVBNJ_G0021938	protein coding gene	Chr15:78077288-78118184 (-)
LP/J	MGP_LPJ_G0022029	protein coding gene	Chr15:82613887-82660764 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021959	protein coding gene	Chr15:93306719-93347693 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022554	protein coding gene	Chr15:81854868-81896666 (-)
PWK/PhJ	MGP_PWKPhJ_G0021129	protein coding gene	Chr15:79079761-79121768 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020968	protein coding gene	Chr15:81651006-81697467 (-)
WSB/EiJ	MGP_WSBEiJ_G0021439	protein coding gene	Chr15:82286053-82326788 (-)

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Human Ortholog

DESI1, desumoylating isopeptidase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DESI1, desumoylating isopeptidase 1
Synonyms

D15Wsu75e, DeSI-1, DESI2, DJ347H13.4, FAM152B, POST, PPPDE2
Links

HGNC:24577

NCBI Gene ID: 27351

neXtProt AC: NX_Q6ICB0

UniProt: Q6ICB0
Chr Location

22q13.2; chr22:41598028-41621043 (-) GRCh38

MGI Vertebrate Homology

Desi1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DESI1
Gene Tree

Desi1

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References

1 with disease annotations

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Phenotype Summary

26 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Desi1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

2
cDNA Data

122
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase desi1

ZFIN desi1a, desi1b

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All Sequences

69
RefSeq

6
UniProt

6
CCDS

CCDS27681.1

Ensembl

ENSMUSG00000022472 (Evidence)
NCBI Gene

28075

Representative Sequences				Length	Strain/Species	Flank
	genomic	28075	NCBI Gene Model \| MGI Sequence Detail	23641	C57BL/6J	± kb
	transcript	NR_177967	RefSeq \| MGI Sequence Detail	3001	C57BL/6
	polypeptide	Q9CQT7	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029409 desumoylating isopeptidase 1

(term hierarchy)
PDB

2WP7
EC

3.1.2.22, 3.4.-.-
InterPro Domains

IPR008580 PPPDE peptidase domain

IPR042266 PPPDE peptidase domain superfamily

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All nucleic 123

cDNA 122

Primer pair 1

Microarray probesets 8

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MGD-MRK-34005, MGI:2146000, MGI:2146086

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Summaries

All 58

Developmental Gene Expression 1

Diseases 1

Gene Ontology 9

Phenotypes 26
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Desi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135522	Chr15:81900404-81900418 (-)	-47 bp
Tssr135521	Chr15:81900375-81900403 (-)	-25 bp
Tssr135520	Chr15:81900335-81900371 (-)	11 bp
Tssr135519	Chr15:81900288-81900330 (-)	55 bp

Desi1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw11	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Bwtq6	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Dbsty4	Chr15, 41.96 cM	Chr15:87349271-87349416	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Mobq4	Chr15, 1.84 cM	Chr15:3489694-3489829	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.

*cM position of peak correlated region/marker

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