Dock9 MGI Mouse Gene Detail - MGI:106321 - dedicator of cytokinesis 9

Symbol

Dock9
Name

dedicator of cytokinesis 9
Synonyms

B230309H04Rik, D14Wsu89e, mKIAA1058, Zizimin1

Feature Type

protein coding gene
IDs

MGI:106321
NCBI Gene: 105445
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr14:121779458-122035249 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 65.28 cM
Mapping Data

4 experiments

SNPs within 2kb

8012 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106321	protein coding gene	Chr14:121772026-122038465 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021663	protein coding gene	Chr14:119365288-119654980 (-)
A/J	MGP_AJ_G0021623	protein coding gene	Chr14:114750673-115012558 (-)
AKR/J	MGP_AKRJ_G0021599	protein coding gene	Chr14:118464085-118735079 (-)
BALB/cJ	MGP_BALBcJ_G0021629	protein coding gene	Chr14:115293863-115559857 (-)
C3H/HeJ	MGP_C3HHeJ_G0021407	protein coding gene	Chr14:118357359-118626544 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022069	protein coding gene	Chr14:123963018-124249276 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019607	protein coding gene	Chr14:110643275-110897446 (-)
CAST/EiJ	MGP_CASTEiJ_G0020922	protein coding gene	Chr14:116255852-116538328 (-)
CBA/J	MGP_CBAJ_G0021375	protein coding gene	Chr14:128687316-128985342 (-)
DBA/2J	MGP_DBA2J_G0021498	protein coding gene	Chr14:114621864-114881002 (-)
FVB/NJ	MGP_FVBNJ_G0021476	protein coding gene	Chr14:112956014-113231902 (-)
LP/J	MGP_LPJ_G0021566	protein coding gene	Chr14:120302132-120576458 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021503	protein coding gene	Chr14:133698447-133982435 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022092	protein coding gene	Chr14:118026320-118306707 (-)
PWK/PhJ	MGP_PWKPhJ_G0020666	protein coding gene	Chr14:111672078-111933492 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020504	protein coding gene	Chr14:114218124-114502394 (-)
WSB/EiJ	MGP_WSBEiJ_G0020978	protein coding gene	Chr14:118736723-119005450 (-)

Human Ortholog

DOCK9, dedicator of cytokinesis 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOCK9, dedicator of cytokinesis 9
Synonyms

ZIZ1, ZIZIMIN1
Links

HGNC:14132

NCBI Gene ID: 23348

neXtProt AC: NX_Q9BZ29

UniProt: Q9BZ29
Chr Location

13q32.3; chr13:98793429-99088619 (-) GRCh38

MGI Vertebrate Homology

Dock9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DOCK9
Gene Tree

Dock9

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

6
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are healthy and viable with no apparent phenotype.

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

5
cDNA Data

184
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock9

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All Sequences

181
RefSeq

93
UniProt

14
CCDS

CCDS37018.1, CCDS49569.1, CCDS84161.1, CCDS84162.1, CCDS88728.1

Ensembl

ENSMUSG00000025558 (Evidence)
NCBI Gene

105445

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025558	Ensembl Gene Model \| MGI Sequence Detail	255792	C57BL/6J	± kb
transcript	ENSMUST00000040700	Ensembl \| MGI Sequence Detail	7803	Not Applicable
polypeptide	ENSMUSP00000047881	Ensembl \| MGI Sequence Detail	2113	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000006626 dedicator of cytokinesis protein 9

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR027007 C2 DOCK-type domain

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR021816 Dedicator of cytokinesis C/D, N-terminal

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR037809 Dedicator of cytokinesis D, C2 domain

IPR027357 DOCKER domain

IPR046769 DOCKER, Lobe A

IPR046770 DOCKER, Lobe B

IPR046773 DOCKER, Lobe C

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 188

cDNA 184

Primer pair 4

Microarray probesets 6

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MGD-MRK-34013, MGI:2145584, MGI:2145822, MGI:2444581

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 9
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dock9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130290	Chr14:122035225-122035272 (-)	0 bp
Tssr130289	Chr14:122035082-122035165 (-)	125 bp
Tssr130288	Chr14:122035051-122035070 (-)	188 bp
Tssr130287	Chr14:122031074-122031080 (-)	4,172 bp
Tssr4534	Chr14:122024901-122024910 (-)	10,343 bp
Tssr130286	Chr14:121983212-121983216 (-)	52,035 bp
Tssr130285	Chr14:121976465-121976482 (-)	58,775 bp
Tssr130284	Chr14:121976326-121976371 (-)	58,900 bp
Tssr130283	Chr14:121976041-121976065 (-)	59,196 bp
Tssr130282	Chr14:121975971-121976015 (-)	59,256 bp
Tssr130281	Chr14:121975955-121975965 (-)	59,289 bp
Tssr130280	Chr14:121975907-121975918 (-)	59,336 bp
Tssr130279	Chr14:121935868-121935877 (-)	99,376 bp
Tssr130278	Chr14:121935832-121935860 (-)	99,403 bp
Tssr130277	Chr14:121935795-121935824 (-)	99,439 bp
Tssr130276	Chr14:121935651-121935662 (-)	99,592 bp
Tssr130275	Chr14:121861460-121861463 (-)	173,787 bp
Tssr130274	Chr14:121834918-121834921 (-)	200,329 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24