Larp4b MGI Mouse Gene Detail - MGI:106330

Symbol

Larp4b
Name

La ribonucleoprotein 4B
Synonyms

D13Wsu64e, Larp5

Feature Type

protein coding gene

BioType Conflict
IDs

MGI:106330
NCBI Gene: 217980
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:9143643-9224487 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, Syntenic
Mapping Data

4 experiments

SNPs within 2kb

1606 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106330	protein coding gene	Chr13:9143643-9224487 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020223	protein coding gene	Chr13:5730268-5814317 (+)
A/J	MGP_AJ_G0020179	protein coding gene	Chr13:5717182-5797721 (+)
AKR/J	MGP_AKRJ_G0020154	protein coding gene	Chr13:5780699-5867511 (+)
BALB/cJ	MGP_BALBcJ_G0020162	protein coding gene	Chr13:5724333-5805865 (+)
C3H/HeJ	MGP_C3HHeJ_G0019966	protein coding gene	Chr13:5904992-5986722 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020609	protein coding gene	Chr13:6088970-6170218 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018216	protein coding gene	Chr13:5663370-5746740 (+)
CAST/EiJ	MGP_CASTEiJ_G0019504	protein coding gene	Chr13:5625711-5707600 (+)
CBA/J	MGP_CBAJ_G0019933	protein coding gene	Chr13:6216435-6302980 (+)
DBA/2J	MGP_DBA2J_G0020050	protein coding gene	Chr13:5546585-5627799 (+)
FVB/NJ	MGP_FVBNJ_G0020035	protein coding gene	Chr13:5400477-5483897 (+)
LP/J	MGP_LPJ_G0020124	protein coding gene	Chr13:5830968-5916393 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020071	protein coding gene	Chr13:6558167-6643465 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020637	protein coding gene	Chr13:5744938-5830364 (+)
PWK/PhJ	MGP_PWKPhJ_G0019267	protein coding gene	Chr13:5579924-5662678 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019074	protein coding gene	Chr13:5733390-5817330 (+)
WSB/EiJ	MGP_WSBEiJ_G0019564	protein coding gene	Chr13:5647444-5729264 (+)

Human Ortholog

LARP4B, La ribonucleoprotein 4B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LARP4B, La ribonucleoprotein 4B
Synonyms

KIAA0217, LARP5
Links

HGNC:28987

NCBI Gene ID: 23185

neXtProt AC: NX_Q92615

UniProt: Q92615
Chr Location

10p15.3; chr10:806914-988341 (-) GRCh38

MGI Vertebrate Homology

Larp4b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LARP4B

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Endonuclease-mediated

2
Gene trapped

50
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

99 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

3
cDNA Data

22
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase larp4b

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All Sequences

70
RefSeq

12
UniProt

3
CCDS

CCDS36588.1, CCDS79162.1

Ensembl

ENSMUSG00000033499 (Evidence), ENSMUSG00000120803 (Evidence)
NCBI Gene

217980

			Length	Strain/Species	Flank
genomic	217980	NCBI Gene Model \| MGI Sequence Detail	80845	C57BL/6J	± kb
transcript	NM_172585	RefSeq \| MGI Sequence Detail	6073	C57BL/6
polypeptide	Q6A0A2	UniProt \| EBI \| MGI Sequence Detail	741	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009671 La-related protein 4B

(term hierarchy)
InterPro Domains

IPR045180 La domain containing protein

IPR034900 LARP5, RNA recognition motif

IPR006630 La-type HTH domain

IPR035979 RNA-binding domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q6A0A2 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 3

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MGD-MRK-34022, MGI:2145195, MGI:3045272

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 13
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Larp4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118307	Chr13:9143850-9143864 (+)	214 bp
Tssr118308	Chr13:9143921-9143928 (+)	282 bp
Tssr118309	Chr13:9143929-9143963 (+)	303 bp
Tssr118310	Chr13:9143995-9144006 (+)	358 bp
Tssr118311	Chr13:9177978-9177995 (+)	34,344 bp
Tssr118312	Chr13:9178000-9178022 (+)	34,368 bp
Tssr118313	Chr13:9195414-9195427 (+)	51,778 bp
Tssr118314	Chr13:9199274-9199281 (+)	55,635 bp
Tssr118315	Chr13:9221363-9221368 (+)	77,723 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24