About   Help   FAQ
Rbfox3 Gene Detail
Summary
  • Symbol
    Rbfox3
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 3
  • Synonyms
    D11Bwg0517e, Hrnbp3, NeuN, Neuna60
  • Feature Type
    protein coding gene
  • IDs
    MGI:106368
    NCBI Gene: 52897
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118380588-118802423 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11854 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106368
 protein coding gene Chr11:118380586-118802423 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019470
 protein coding gene Chr11:122814789-123253315 (-)
A/J MGP_AJ_G0019438
 protein coding gene Chr11:117377110-117804474 (-)
AKR/J MGP_AKRJ_G0019408
 protein coding gene Chr11:120935566-121364193 (-)
BALB/cJ MGP_BALBcJ_G0019413
 protein coding gene Chr11:117738624-118165077 (-)
C3H/HeJ MGP_C3HHeJ_G0019219
 protein coding gene Chr11:121243515-121674703 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019862
 protein coding gene Chr11:126577557-127017805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017487
 protein coding gene Chr11:114375468-114802892 (-)
CAST/EiJ MGP_CASTEiJ_G0018773
 protein coding gene Chr11:122669842-123108097 (-)
CBA/J MGP_CBAJ_G0019190
 protein coding gene Chr11:131491707-131946552 (-)
DBA/2J MGP_DBA2J_G0019302
 protein coding gene Chr11:116757726-117182838 (-)
FVB/NJ MGP_FVBNJ_G0019294
 protein coding gene Chr11:116406651-116839959 (-)
LP/J MGP_LPJ_G0019372
 protein coding gene Chr11:123137534-123571955 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019327
 protein coding gene Chr11:130484320-130923495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019901
 protein coding gene Chr11:121598875-122029223 (-)
PWK/PhJ MGP_PWKPhJ_G0018539
 protein coding gene Chr11:118146301-118575995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018331
 protein coding gene Chr11:121318425-121768900 (-)
WSB/EiJ MGP_WSBEiJ_G0018825
 protein coding gene Chr11:121554750-121993946 (-)



Homology
more
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
  • Synonyms
    FOX-3, FOX3, HRNBP3, NEUN
  • Links
    NCBI Gene ID: 146713
    neXtProt AC: NX_A6NFN3
    UniProt: A6NFN3

  • Chr Location
    17q25.3; chr17:79089345-79665571 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced brain weight, increased susceptibility kainic acid-induced seizures, decreased anxiety-related behaviors, and deficits in synaptic transmission and plasticity in the dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1590
  • Tissues
    243
  • cDNA Data
    22
  • Literature Summary
    972
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025576 Ensembl Gene Model | MGI Sequence Detail 421836 C57BL/6J ±  kb
    transcript ENSMUST00000017576 Ensembl | MGI Sequence Detail 3150 Not Applicable  
    polypeptide ENSMUSP00000017576 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006252 RNA binding protein fox-1 homolog 3
      (term hierarchy)
    • InterPro Domains
      IPR025670 Fox-1 C-terminal domain
      IPR034237 FOX1, RNA recognition motif
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR017325 RNA binding protein fox-1 homolog 1-3
      IPR047131 RNA binding protein fox-1 homolog 1-like
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q8BIF2 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 25
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34061, MGI:1929613
    References
    more
    • Summaries
      All 1045
      Developmental Gene Expression 972
      Gene Ontology 24
      Phenotypes 13
    • Earliest
      J:31592 Mullen RJ, et al., NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992 Sep;116(1):201-11
    • Latest
      J:357551 Ge Y, et al., Haploinsufficiency of GABA(A) Receptor-Associated Clptm1 Enhances Phasic and Tonic Inhibitory Neurotransmission, Suppresses Excitatory Synaptic Plasticity, and Impairs Memory. J Neurosci. 2024 Aug 7;44(32)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory