Nhsl1 MGI Mouse Gene Detail - MGI:106390 - NHS like 1

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Nhsl1 Gene Detail

Symbol

Nhsl1
Name

NHS like 1
Synonyms

5730409E15Rik, A630035H13Rik, D10Bwg0940e

Feature Type

protein coding gene
IDs

MGI:106390
NCBI Gene: 215819
Alliance

gene page
Transcription Start Sites

25 TSS

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Sequence Map

Chr10:18194733-18409640 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 7.65 cM, cytoband A2
Mapping Data

4 experiments

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SNPs within 2kb

6821 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_106390	protein coding gene	Chr10:18193419-18409640 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017038	protein coding gene	Chr10:16070704-16218048 (+)
A/J	MGP_AJ_G0017016	protein coding gene	Chr10:15451576-15596259 (+)
AKR/J	MGP_AKRJ_G0016980	protein coding gene	Chr10:15709530-15856436 (+)
BALB/cJ	MGP_BALBcJ_G0016974	protein coding gene	Chr10:15513793-15662397 (+)
C3H/HeJ	MGP_C3HHeJ_G0016799	protein coding gene	Chr10:16036817-16181474 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017436	protein coding gene	Chr10:16462975-16618711 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015141	protein coding gene	Chr10:14329336-14473402 (+)
CAST/EiJ	MGP_CASTEiJ_G0016381	protein coding gene	Chr10:15836564-15986299 (+)
CBA/J	MGP_CBAJ_G0016771	protein coding gene	Chr10:17199312-17352719 (+)
DBA/2J	MGP_DBA2J_G0016879	protein coding gene	Chr10:15341444-15492152 (+)
FVB/NJ	MGP_FVBNJ_G0016874	protein coding gene	Chr10:15108042-15252996 (+)
LP/J	MGP_LPJ_G0016954	protein coding gene	Chr10:15883624-16029998 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016904	protein coding gene	Chr10:17537685-17691633 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017474	protein coding gene	Chr10:15677853-15831367 (+)
PWK/PhJ	MGP_PWKPhJ_G0016166	protein coding gene	Chr10:15180439-15326991 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015949	protein coding gene	Chr10:15817668-15971032 (+)
WSB/EiJ	MGP_WSBEiJ_G0016443	protein coding gene	Chr10:15766176-15917413 (+)

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Human Ortholog

NHSL1, NHS like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NHSL1, NHS like 1
Synonyms

C6orf63
Links

HGNC:21021

NCBI Gene ID: 57224

neXtProt AC: NX_Q5SYE7

UniProt: Q5SYE7
Chr Location

6q24.1

MGI Vertebrate Homology

Nhsl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NHSL1
Gene Tree

Nhsl1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

19
Targeted

2
Genomic Mutations

1 involving Nhsl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

20
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nhsl1

ZFIN nhsl1a, nhsl1b

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All Sequences

85
RefSeq

34
UniProt

3
CCDS

CCDS35853.1, CCDS48508.1

Ensembl

ENSMUSG00000039835 (Evidence)
NCBI Gene

215819

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000039835	Ensembl Gene Model \| MGI Sequence Detail	214908	C57BL/6J	± kb
	transcript	ENSMUST00000207038	Ensembl \| MGI Sequence Detail	4854	Not Applicable
	polypeptide	ENSMUSP00000147021	Ensembl \| MGI Sequence Detail	1617	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011205 NHS-like protein 1

(term hierarchy)
InterPro Domains

IPR024845 Actin remodeling regulator NHS-like
GlyGen

Q8CAF4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGD-MRK-34083, MGI:1917752, MGI:2444499, MGI:2674131

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Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nhsl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92473	Chr10:18194345-18194370 (+)	-375 bp
Tssr92474	Chr10:18194381-18194473 (+)	-306 bp
Tssr92475	Chr10:18232066-18232071 (+)	37,336 bp
Tssr92476	Chr10:18236750-18236752 (+)	42,018 bp
Tssr92477	Chr10:18283374-18283398 (+)	88,653 bp
Tssr92478	Chr10:18283406-18283463 (+)	88,702 bp
Tssr92479	Chr10:18283526-18283531 (+)	88,796 bp
Tssr92480	Chr10:18283584-18283603 (+)	88,861 bp
Tssr92481	Chr10:18306925-18306934 (+)	112,197 bp
Tssr92482	Chr10:18306953-18306986 (+)	112,237 bp
Tssr92483	Chr10:18306991-18307013 (+)	112,269 bp
Tssr92484	Chr10:18307015-18307030 (+)	112,290 bp
Tssr92485	Chr10:18307040-18307052 (+)	112,313 bp
Tssr92486	Chr10:18307205-18307211 (+)	112,475 bp
Tssr92487	Chr10:18323073-18323077 (+)	128,342 bp
Tssr92488	Chr10:18345625-18345626 (+)	150,893 bp
Tssr92489	Chr10:18345651-18345658 (+)	150,922 bp
Tssr92490	Chr10:18345686-18345697 (+)	150,959 bp
Tssr92491	Chr10:18345706-18345722 (+)	150,981 bp
Tssr92492	Chr10:18351582-18351586 (+)	156,851 bp
Tssr92493	Chr10:18384587-18384597 (+)	189,859 bp
Tssr92494	Chr10:18401685-18401702 (+)	206,961 bp
Tssr92495	Chr10:18402084-18402087 (+)	207,353 bp
Tssr92496	Chr10:18402365-18402374 (+)	207,637 bp
Tssr92497	Chr10:18408452-18408456 (+)	213,721 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24