Washc2 MGI Mouse Gene Detail - MGI:106463

Symbol

Washc2
Name

WASH complex subunit 2
Synonyms

C530005J20Rik, D6Wsu116e, Fam21

Feature Type

protein coding gene
IDs

MGI:106463
NCBI Gene: 28006
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:116184988-116239632 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 53.76 cM, cytoband F1
Mapping Data

5 experiments

SNPs within 2kb

1505 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106463	protein coding gene	Chr6:116184988-116239647 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031163	protein coding gene	Chr6:118865465-118924637 (+)
A/J	MGP_AJ_G0031133	protein coding gene	Chr6:114309603-114365153 (+)
AKR/J	MGP_AKRJ_G0031063	protein coding gene	Chr6:117361347-117420098 (+)
BALB/cJ	MGP_BALBcJ_G0031143	protein coding gene	Chr6:114117145-114170620 (+)
C3H/HeJ	MGP_C3HHeJ_G0030565	protein coding gene	Chr6:66865923-66928177 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031602	protein coding gene	Chr6:121906022-121976008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028766	protein coding gene	Chr6:111311891-111366343 (+)
CAST/EiJ	MGP_CASTEiJ_G0030250	protein coding gene	Chr6:117756298-117807069 (+)
CBA/J	MGP_CBAJ_G0030829	protein coding gene	Chr6:126691693-126758968 (+)
DBA/2J	MGP_DBA2J_G0030983	protein coding gene	Chr6:113226221-113279981 (+)
FVB/NJ	MGP_FVBNJ_G0030936	protein coding gene	Chr6:112416436-112470642 (+)
LP/J	MGP_LPJ_G0031062	protein coding gene	Chr6:118876209-118934836 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030971	protein coding gene	Chr6:130845277-130904137 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031630	protein coding gene	Chr6:117395630-117462776 (+)
PWK/PhJ	MGP_PWKPhJ_G0029966	protein coding gene	Chr6:112243912-112298382 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029794	protein coding gene	Chr6:116139520-116198411 (+)
WSB/EiJ	MGP_WSBEiJ_G0030334	protein coding gene	Chr6:117670561-117726417 (+)

Human Ortholog

WASHC2A, WASH complex subunit 2A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WASHC2A, WASH complex subunit 2A
Synonyms

bA56A21.1, bA98I6.1, FAM21A, FAM21B
Links

HGNC:23416

NCBI Gene ID: 387680

neXtProt AC: NX_Q641Q2

UniProt: Q641Q2
Chr Location

10q11.23

Human Ortholog

WASHC2C, WASH complex subunit 2C
Synonyms

FAM21A, FAM21C, VPEF
Links

HGNC:23414

NCBI Gene ID: 253725

neXtProt AC: NX_Q9Y4E1

UniProt: Q9Y4E1
Chr Location

10q11.22; chr10:45727043-45792964 (+) GRCh38

MGI Vertebrate Homology

Washc2 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WASHC2A, WASHC2C
Gene Tree

Washc2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

7
Targeted

6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit placentation defects with abnormal trophoblast layer formation and complete lethality throughout fetal growth and development.

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All GO Annotations

35
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

10
cDNA Data

198
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

85
RefSeq

9
UniProt

8
CCDS

CCDS20450.1

Ensembl

ENSMUSG00000024104 (Evidence)
NCBI Gene

28006

			Length	Strain/Species	Flank
genomic	28006	NCBI Gene Model \| MGI Sequence Detail	54645	C57BL/6J	± kb
transcript	NM_026585	RefSeq \| MGI Sequence Detail	4305	ZRU/MplStud
polypeptide	Q6PGL7	UniProt \| EBI \| MGI Sequence Detail	1334	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007728 WASH complex subunit 2

(term hierarchy)
InterPro Domains

IPR029341 FAM21/CAPZIP domain

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All nucleic 201

cDNA 200

Primer pair 1

Microarray probesets 4

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MGD-MRK-34157, MGI:1915404

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 14
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Washc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58354	Chr6:116184991-116185075 (+)	45 bp
Tssr58355	Chr6:116185077-116185091 (+)	96 bp
Tssr58356	Chr6:116185146-116185158 (+)	164 bp
Tssr58357	Chr6:116203219-116203225 (+)	18,234 bp
Tssr58358	Chr6:116203927-116203941 (+)	18,946 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24