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Mepce Gene Detail
Summary
  • Symbol
    Mepce
  • Name
    methylphosphate capping enzyme
  • Synonyms
    Bcdin3, D5Wsu46e, MGC:28888, MGC:30590
  • Feature Type
    protein coding gene
  • IDs
    MGI:106477
    NCBI Gene: 231803
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137780168-137785915 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106477
 protein coding gene Chr5:137780168-137785917 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030244
 protein coding gene Chr5:142578082-142583831 (-)
A/J MGP_AJ_G0030212
 protein coding gene Chr5:136357564-136363313 (-)
AKR/J MGP_AKRJ_G0030145
 protein coding gene Chr5:140786990-140792736 (-)
BALB/cJ MGP_BALBcJ_G0030222
 protein coding gene Chr5:137744125-137749874 (-)
C3H/HeJ MGP_C3HHeJ_G0029938
 protein coding gene Chr5:141449281-141455030 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030674
 protein coding gene Chr5:147841705-147847454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027892
 protein coding gene Chr5:130589618-130595402 (-)
CAST/EiJ MGP_CASTEiJ_G0029348
 protein coding gene Chr5:140846977-140852720 (-)
CBA/J MGP_CBAJ_G0029908
 protein coding gene Chr5:153727769-153733518 (-)
DBA/2J MGP_DBA2J_G0030059
 protein coding gene Chr5:136267296-136273045 (-)
FVB/NJ MGP_FVBNJ_G0030014
 protein coding gene Chr5:135460116-135465865 (-)
LP/J MGP_LPJ_G0030148
 protein coding gene Chr5:143059394-143065265 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030046
 protein coding gene Chr5:156541874-156548414 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030715
 protein coding gene Chr5:140642947-140648696 (-)
PWK/PhJ MGP_PWKPhJ_G0029061
 protein coding gene Chr5:135345396-135351137 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028897
 protein coding gene Chr5:138207696-138213445 (-)
WSB/EiJ MGP_WSBEiJ_G0029421
 protein coding gene Chr5:141372744-141378493 (-)



Homology
more
  • Human Ortholog
    MEPCE, methylphosphate capping enzyme
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEPCE, methylphosphate capping enzyme
  • Synonyms
    BCDIN3
  • Links
    NCBI Gene ID: 56257
    neXtProt AC: NX_Q7L2J0
    UniProt: Q7L2J0

  • Chr Location
    7q22.1; chr7:100428322-100434126 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    39
  • cDNA Data
    69
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 231803 NCBI Gene Model | MGI Sequence Detail 5748 C57BL/6J ±  kb
transcript NM_144913 RefSeq | MGI Sequence Detail 3125 C57BL/6  
polypeptide Q8K3A9 UniProt | EBI | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010326 7SK snRNA methylphosphate capping enzyme
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR024160 Bin3-type S-adenosyl-L-methionine binding domain
    IPR025714 Methyltransferase domain
    IPR010675 RNA methyltransferase bin3, C-terminal
    IPR039772 RNA methyltransferase Bin3-like
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
  • GlyGen
    Q8K3A9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 71
    cDNA 69
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-34171
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory