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Chpf Gene Detail
Summary
  • Symbol
    Chpf
  • Name
    chondroitin polymerizing factor
  • Synonyms
    1700028N03Rik, D1Bwg1363e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106576
    NCBI Gene: 74241
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75451213-75455951 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 39.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106576
 protein coding gene Chr1:75451213-75456115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016189
 protein coding gene Chr1:76052328-76057118 (-)
A/J MGP_AJ_G0016172
 protein coding gene Chr1:73398641-73403393 (-)
AKR/J MGP_AKRJ_G0016129
 protein coding gene Chr1:75432581-75437317 (-)
BALB/cJ MGP_BALBcJ_G0016127
 protein coding gene Chr1:73461245-73465990 (-)
C3H/HeJ MGP_C3HHeJ_G0015958
 protein coding gene Chr1:75765482-75770223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016580
 protein coding gene Chr1:79006531-79011277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014301
 protein coding gene Chr1:68957771-68962281 (-)
CAST/EiJ MGP_CASTEiJ_G0015542
 protein coding gene Chr1:75110482-75115218 (-)
CBA/J MGP_CBAJ_G0015931
 protein coding gene Chr1:81584056-81588798 (-)
DBA/2J MGP_DBA2J_G0016032
 protein coding gene Chr1:72717990-72722729 (-)
FVB/NJ MGP_FVBNJ_G0016035
 protein coding gene Chr1:71924154-71928892 (-)
LP/J MGP_LPJ_G0016104
 protein coding gene Chr1:77179700-77184438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016055
 protein coding gene Chr1:84918594-84923330 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016627
 protein coding gene Chr1:75502474-75507207 (-)
PWK/PhJ MGP_PWKPhJ_G0015329
 protein coding gene Chr1:72193945-72199120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015107
 protein coding gene Chr1:74858437-74862800 (-)
WSB/EiJ MGP_WSBEiJ_G0015604
 protein coding gene Chr1:75312045-75316776 (-)



Homology
more
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Synonyms
    CHPF1, CHSY2, CSS2
  • Links
    NCBI Gene ID: 79586
    neXtProt AC: NX_Q8IZ52
    UniProt: Q8IZ52

  • Chr Location
    2q35; chr2:219538954-219543809 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are viable and no detectable mutant phenotype is reported. Mice homozygous for another knock-out allele exhibit slight reduction in femur and tibia length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    99
  • cDNA Data
    58
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032997 Ensembl Gene Model | MGI Sequence Detail 4739 C57BL/6J ±  kb
    transcript ENSMUST00000079205 Ensembl | MGI Sequence Detail 2892 Not Applicable  
    polypeptide ENSMUSP00000078199 Ensembl | MGI Sequence Detail 774 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 2
      cDNA 58
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34270, MGI:1921491, MGI:2138222
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory