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Hivep3 Gene Detail
Summary
  • Symbol
    Hivep3
  • Name
    human immunodeficiency virus type I enhancer binding protein 3
  • Synonyms
    2900056N03Rik, E030045D18Rik, Krc, Schnurri-3, Shn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106589
    NCBI Gene: 16656
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119590982-119992608 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.51 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10235 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106589
 protein coding gene Chr4:119590981-119995242 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028705
 protein coding gene Chr4:120940178-121369545 (+)
A/J MGP_AJ_G0028665
 protein coding gene Chr4:116187604-116596551 (+)
AKR/J MGP_AKRJ_G0028618
 protein coding gene Chr4:118727367-119139705 (+)
BALB/cJ MGP_BALBcJ_G0028688
 protein coding gene Chr4:116814395-117217000 (+)
C3H/HeJ MGP_C3HHeJ_G0028403
 protein coding gene Chr4:120282598-120694242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029129
 protein coding gene Chr4:125533653-125953723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026406
 protein coding gene Chr4:110281106-110686752 (+)
CAST/EiJ MGP_CASTEiJ_G0027834
 protein coding gene Chr4:117607765-118031982 (+)
CBA/J MGP_CBAJ_G0028370
 protein coding gene Chr4:128929627-129364820 (+)
DBA/2J MGP_DBA2J_G0028517
 protein coding gene Chr4:116775203-117188436 (+)
FVB/NJ MGP_FVBNJ_G0028483
 protein coding gene Chr4:115291022-115700503 (+)
LP/J MGP_LPJ_G0028617
 protein coding gene Chr4:121072616-121504391 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028511
 protein coding gene Chr4:133815908-134240102 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029166
 protein coding gene Chr4:119798164-120212255 (+)
PWK/PhJ MGP_PWKPhJ_G0027557
 protein coding gene Chr4:113706234-114115869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027383
 protein coding gene Chr4:116227638-116638694 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HIVEP3, HIVEP zinc finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIVEP3, HIVEP zinc finger 3
  • Synonyms
    KBP-1, KBP1, KRC, Schnurri-3, SHN3, ZAS3, ZNF40C
  • Links
    NCBI Gene ID: 59269
    neXtProt AC: NX_Q5T1R4
    UniProt: Q5T1R4

  • Chr Location
    1p34.2; chr1:41506365-42035934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    61
  • cDNA Data
    19
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16656 NCBI Gene Model | MGI Sequence Detail 401627 C57BL/6J ±  kb
    transcript NM_010657 RefSeq | MGI Sequence Detail 9021 Not Specified  
    polypeptide A2A884 UniProt | EBI | MGI Sequence Detail 2348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-35045, MGI:1920253, MGI:2140378, MGI:2443550
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:15696 Wu LC, et al., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993 Nov 11;21(22):5067-73
    • Latest
      J:358109 Stavre Z, et al., Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2218019120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory