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Gk Gene Detail
Summary
  • Symbol
    Gk
  • Name
    glycerol kinase
  • Synonyms
    D930012N15Rik, Gyk
  • Feature Type
    protein coding gene
  • IDs
    MGI:106594
    NCBI Gene: 14933
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:84745543-84820425 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 39.32 cM, cytoband C-D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1812 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106594
 protein coding gene ChrX:84745543-84820425 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035889
 protein coding gene ChrX:81788568-81866802 (-)
A/J MGP_AJ_G0035874
 protein coding gene ChrX:81885021-81966394 (-)
AKR/J MGP_AKRJ_G0035792
 protein coding gene ChrX:84049980-84133316 (-)
BALB/cJ MGP_BALBcJ_G0035855
 protein coding gene ChrX:80613996-80691846 (-)
C3H/HeJ MGP_C3HHeJ_G0035565
 protein coding gene ChrX:82080276-82157029 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036386
 protein coding gene ChrX:84287934-84365863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033217
 protein coding gene ChrX:80777907-80852389 (-)
CAST/EiJ MGP_CASTEiJ_G0034854
 protein coding gene ChrX:67043341-67120686 (-)
CBA/J MGP_CBAJ_G0035540
 protein coding gene ChrX:86581323-86659348 (-)
DBA/2J MGP_DBA2J_G0035695
 protein coding gene ChrX:81275700-81350693 (-)
FVB/NJ MGP_FVBNJ_G0035634
 protein coding gene ChrX:80682954-80760685 (-)
LP/J MGP_LPJ_G0035784
 protein coding gene ChrX:82574752-82650426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035671
 protein coding gene ChrX:90069381-90148948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036413
 protein coding gene ChrX:81498585-81570157 (-)
PWK/PhJ MGP_PWKPhJ_G0034552
 protein coding gene ChrX:65079532-65152147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034382
 protein coding gene ChrX:67967844-68052445 (-)
WSB/EiJ MGP_WSBEiJ_G0034993
 protein coding gene ChrX:80399332-80482850 (-)



Homology
more
  • Human Ortholog
    GK, glycerol kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GK, glycerol kinase
  • Synonyms
    GK1, GKD
  • Links
    NCBI Gene ID: 2710
    neXtProt AC: NX_P32189
    UniProt: P32189

  • Chr Location
    Xp21.2; chrX:30653359-30731462 (+)  GRCh38
  • MGI Vertebrate Homology
    Gk stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: GK
  • Protein SuperFamily
    GlpK
  • Gene Tree
    Gk
Human Diseases
more
  • Diseases
    1 with Gk mouse models; 1 with human GK associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for a targeted null mutation show postnatal growth retardation, altered fat metabolism with severe hyperglycerolemia and increased free fatty acids, autonomous glucocorticoid synthesis and death by 4 days of age. Female heterozygotes show reduced free fatty acid and glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    173
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14933 NCBI Gene Model | MGI Sequence Detail 74883 C57BL/6J ±  kb
    transcript NM_001294140 RefSeq | MGI Sequence Detail 4462 ZRU/MplStud  
    polypeptide Q64516 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 20
      Primer pair 5
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35050, MGI:2442000
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 16
      Phenotypes 16
    • Earliest
      J:34208 Huq AH, et al., Isolation, mapping, and functional expression of the mouse X chromosome glycerol kinase gene. Genomics. 1996 Sep 15;36(3):530-4
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory