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Myo5b Gene Detail
Summary
  • Symbol
    Myo5b
  • Name
    myosin VB
  • Feature Type
    protein coding gene
  • IDs
    MGI:106598
    NCBI Gene: 17919
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:74575435-74905769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.70 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11897 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106598
 protein coding gene Chr18:74574007-74905769 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024558
 protein coding gene Chr18:75079077-75418539 (+)
A/J MGP_AJ_G0024525
 protein coding gene Chr18:71808964-72128395 (+)
AKR/J MGP_AKRJ_G0024496
 protein coding gene Chr18:73923708-74254335 (+)
BALB/cJ MGP_BALBcJ_G0024525
 protein coding gene Chr18:72000603-72327799 (+)
C3H/HeJ MGP_C3HHeJ_G0024293
 protein coding gene Chr18:74034769-74364817 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024971
 protein coding gene Chr18:77040732-77388892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022401
 protein coding gene Chr18:70866069-71181933 (+)
CAST/EiJ MGP_CASTEiJ_G0023766
 protein coding gene Chr18:74197514-74535447 (+)
CBA/J MGP_CBAJ_G0024262
 protein coding gene Chr18:79680312-80039338 (+)
DBA/2J MGP_DBA2J_G0024392
 protein coding gene Chr18:71405605-71726491 (+)
FVB/NJ MGP_FVBNJ_G0024358
 protein coding gene Chr18:70740625-71057239 (+)
LP/J MGP_LPJ_G0024476
 protein coding gene Chr18:74955809-75285234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024388
 protein coding gene Chr18:81145090-81492373 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025019
 protein coding gene Chr18:74078623-74409577 (+)
PWK/PhJ MGP_PWKPhJ_G0023510
 protein coding gene Chr18:71772661-72092604 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023314
 protein coding gene Chr18:74203672-74533165 (+)
WSB/EiJ MGP_WSBEiJ_G0023829
 protein coding gene Chr18:74010097-74343812 (+)



Homology
more
  • Human Ortholog
    MYO5B, myosin VB
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO5B, myosin VB
  • Synonyms
    DIAR2, MVID1, PFIC10
  • Links
    NCBI Gene ID: 4645
    neXtProt AC: NX_Q9ULV0
    UniProt: Q9ULV0

  • Chr Location
    18q21.1; chr18:49822789-50195164 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Myo5b mouse models; 2 with human MYO5B associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show perinatal mortality, diarrhea, intestinal microvillus atrophy and the presence of microvillus inclusion bodies, resembling phenotype of Microvillus Inclusion Disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    55
  • cDNA Data
    48
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17919 NCBI Gene Model | MGI Sequence Detail 330335 C57BL/6J ±  kb
    transcript NM_201600 RefSeq | MGI Sequence Detail 6647 ZRU/MplStud  
    polypeptide P21271 UniProt | EBI | MGI Sequence Detail 1818 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 53
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35054, MGI:2147254
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:36578 Huang WM, et al., Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8491-5
    • Latest
      J:345080 Dooley SA, et al., Myosin 5b is required for proper localization of the intermicrovillar adhesion complex in the intestinal brush border. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 1;323(5):G501-G510
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory