Serpinb9 MGI Mouse Gene Detail - MGI:106603 - serine (or cysteine) peptidase inhibitor, clade B, member 9

Symbol

Serpinb9
Name

serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms

ovalbumin, PI-9, Spi6

Feature Type

protein coding gene
IDs

MGI:106603
NCBI Gene: 20723
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:33187233-33201940 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.79 cM
Mapping Data

5 experiments

SNPs within 2kb

571 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106603	protein coding gene	Chr13:33181044-33201940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020431	protein coding gene	Chr13:31009855-31024553 (+)
A/J	MGP_AJ_G0020386	protein coding gene	Chr13:30156479-30171194 (+)
AKR/J	MGP_AKRJ_G0020363	protein coding gene	Chr13:30818917-30833616 (+)
BALB/cJ	MGP_BALBcJ_G0020381	protein coding gene	Chr13:30238960-30253916 (+)
C3H/HeJ	MGP_C3HHeJ_G0020184	protein coding gene	Chr13:30809105-30823803 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020817	protein coding gene	Chr13:32032505-32047350 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018408	protein coding gene	Chr13:28476156-28492004 (+)
CAST/EiJ	MGP_CASTEiJ_G0019701	protein coding gene	Chr13:30531507-30546798 (+)
CBA/J	MGP_CBAJ_G0020140	protein coding gene	Chr13:33438108-33455238 (+)
DBA/2J	MGP_DBA2J_G0020262	protein coding gene	Chr13:29665771-29681109 (+)
FVB/NJ	MGP_FVBNJ_G0020247	protein coding gene	Chr13:29289638-29304346 (+)
LP/J	MGP_LPJ_G0020339	protein coding gene	Chr13:31225721-31242213 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020273	protein coding gene	Chr13:33522532-33537179 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020858	protein coding gene	Chr13:30493378-30508074 (+)
PWK/PhJ	MGP_PWKPhJ_G0019456	protein coding gene	Chr13:29861061-29876938 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019277	protein coding gene	Chr13:29401188-29417362 (+)
WSB/EiJ	MGP_WSBEiJ_G0019763	protein coding gene	Chr13:30807773-30822492 (+)

Human Ortholog

SERPINB9, serpin family B member 9

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB9, serpin family B member 9
Synonyms

CAP-3, CAP3, PI-9, PI9
Links

HGNC:8955

NCBI Gene ID: 5272

neXtProt AC: NX_P50453

UniProt: P50453
Chr Location

6p25.2; chr6:2887270-2903309 (-) GRCh38

MGI Vertebrate Homology

Serpinb9 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: SERPINB9
Gene Tree

Serpinb9

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Serpinb9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show defective CTL immunity and clearance of LCMV. Following infection with LCMV or L. monocytogenes, mutant CTLs display a breakdown of cytotoxic granule integrity, increased cytoplasmic granzyme B, and reduced survival due to increased granzyme B-mediated apoptosis.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

59
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

6
UniProt

1
CCDS

CCDS26431.1

Ensembl

ENSMUSG00000045827 (Evidence)
NCBI Gene

20723

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045827	Ensembl Gene Model \| MGI Sequence Detail	14708	C57BL/6J	± kb
transcript	ENSMUST00000006391	Ensembl \| MGI Sequence Detail	3397	Not Applicable
polypeptide	ENSMUSP00000006391	Ensembl \| MGI Sequence Detail	374	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR000240 Serpin B9/maspin

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 62

Genomic 2

cDNA 60

Microarray probesets 4

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MGD-MRK-35059, MGI:3035078

Summaries

All 53

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 28
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Serpinb9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119163	Chr13:33186023-33186051 (+)	-1,196 bp
Tssr119164	Chr13:33187141-33187161 (+)	-82 bp
Tssr119165	Chr13:33187205-33187240 (+)	-10 bp
Tssr119166	Chr13:33187439-33187454 (+)	214 bp
Tssr119167	Chr13:33188141-33188144 (+)	910 bp
Tssr119168	Chr13:33188511-33188536 (+)	1,291 bp
Tssr119169	Chr13:33188546-33188561 (+)	1,321 bp
Tssr119170	Chr13:33188579-33188592 (+)	1,353 bp
Tssr119171	Chr13:33188603-33188623 (+)	1,380 bp
Tssr119172	Chr13:33197905-33197930 (+)	10,685 bp
Tssr119173	Chr13:33199907-33199920 (+)	12,681 bp
Tssr119174	Chr13:33200128-33200146 (+)	12,904 bp
Tssr119175	Chr13:33200167-33200215 (+)	12,958 bp
Tssr119176	Chr13:33201108-33201118 (+)	13,880 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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