Gpld1 MGI Mouse Gene Detail - MGI:106604 - glycosylphosphatidylinositol specific phospholipase D1

Symbol

Gpld1
Name

glycosylphosphatidylinositol specific phospholipase D1
Synonyms

6330541J12Rik

Feature Type

protein coding gene
IDs

MGI:106604
NCBI Gene: 14756
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr13:25127135-25175919 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 10.79 cM
Mapping Data

7 experiments

SNPs within 2kb

1578 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106604	protein coding gene	Chr13:25127135-25176484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020385	protein coding gene	Chr13:22442530-22496384 (+)
A/J	MGP_AJ_G0020334	protein coding gene	Chr13:22025677-22078886 (+)
AKR/J	MGP_AKRJ_G0020314	protein coding gene	Chr13:22273653-22327260 (+)
BALB/cJ	MGP_BALBcJ_G0020332	protein coding gene	Chr13:22009665-22066475 (+)
C3H/HeJ	MGP_C3HHeJ_G0020136	protein coding gene	Chr13:22348236-22401923 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020769	protein coding gene	Chr13:23240033-23292670 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018357	protein coding gene	Chr13:20748576-20796524 (+)
CAST/EiJ	MGP_CASTEiJ_G0019653	protein coding gene	Chr13:22073942-22124948 (+)
CBA/J	MGP_CBAJ_G0020090	protein coding gene	Chr13:24128037-24181713 (+)
DBA/2J	MGP_DBA2J_G0020216	protein coding gene	Chr13:21523692-21571623 (+)
FVB/NJ	MGP_FVBNJ_G0020200	protein coding gene	Chr13:21166240-21222505 (+)
LP/J	MGP_LPJ_G0020289	protein coding gene	Chr13:22735922-22789032 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020227	protein coding gene	Chr13:24381214-24435096 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020811	protein coding gene	Chr13:22121786-22184203 (+)
PWK/PhJ	MGP_PWKPhJ_G0019407	protein coding gene	Chr13:21547658-21596643 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019223	protein coding gene	Chr13:20957788-21013621 (+)
WSB/EiJ	MGP_WSBEiJ_G0019713	protein coding gene	Chr13:22292950-22341164 (+)

Human Ortholog

GPLD1, glycosylphosphatidylinositol specific phospholipase D1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPLD1, glycosylphosphatidylinositol specific phospholipase D1
Synonyms

GPIPLD, GPIPLDM, PIGPLD, PIGPLD1, PLD
Links

HGNC:4459

NCBI Gene ID: 2822

neXtProt AC: NX_P80108

UniProt: P80108
Chr Location

6p22.3; chr6:24423969-24495287 (-) GRCh38

MGI Vertebrate Homology

Gpld1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPLD1
Gene Tree

Gpld1

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Gpld1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

63
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

128
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpld1

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All Sequences

48
RefSeq

6
UniProt

5
CCDS

CCDS26384.1

Ensembl

ENSMUSG00000021340 (Evidence)
NCBI Gene

14756

			Length	Strain/Species	Flank
genomic	14756	NCBI Gene Model \| MGI Sequence Detail	48785	C57BL/6J	± kb
transcript	NM_008156	RefSeq \| MGI Sequence Detail	4659	ZRU/MplStud
polypeptide	O70362	UniProt \| EBI \| MGI Sequence Detail	837	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008177 phosphatidylinositol-glycan-specific phospholipase D

(term hierarchy)
EC

3.1.4.50
InterPro Domains

IPR013517 FG-GAP repeat

IPR001028 Glycoprotein phospholipase D

IPR013519 Integrin alpha beta-propellor

IPR028994 Integrin alpha, N-terminal

IPR029002 Phospholipase C/D
GlyGen

O70362 17 sites, 12 N-linked glycans (12 sites)

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 6

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MGD-MRK-35061, MGI:1924474, MGI:2145449

Summaries

All 57

Developmental Gene Expression 3

Gene Ontology 13

Phenotypes 19
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:351315 Ren T, et al., Exercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity. Sci Adv. 2024 May 31;10(22):eadk5011

TSS for Gpld1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118982	Chr13:25126673-25126694 (+)	-451 bp
Tssr118983	Chr13:25126697-25126747 (+)	-413 bp
Tssr118984	Chr13:25126878-25126913 (+)	-239 bp
Tssr118985	Chr13:25127127-25127147 (+)	2 bp
Tssr118986	Chr13:25127148-25127159 (+)	19 bp
Tssr118987	Chr13:25127163-25127190 (+)	42 bp
Tssr118988	Chr13:25127195-25127205 (+)	65 bp
Tssr118989	Chr13:25127468-25127492 (+)	345 bp
Tssr118990	Chr13:25127501-25127514 (+)	373 bp
Tssr118991	Chr13:25127525-25127545 (+)	400 bp
Tssr118992	Chr13:25127550-25127559 (+)	420 bp
Tssr118993	Chr13:25127561-25127576 (+)	434 bp
Tssr118994	Chr13:25127578-25127589 (+)	449 bp
Tssr118995	Chr13:25148262-25148268 (+)	21,130 bp
Tssr118996	Chr13:25174349-25174392 (+)	47,236 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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