Myo1c MGI Mouse Gene Detail - MGI:106612

Symbol

Myo1c
Name

myosin IC
Synonyms

C80397, mm1beta, myosin-Ibeta, myr2

Feature Type

protein coding gene
IDs

MGI:106612
NCBI Gene: 17913
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr11:75541330-75564736 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM, cytoband C-E1
Mapping Data

11 experiments

SNPs within 2kb

528 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106612	protein coding gene	Chr11:75541330-75565450 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018720	protein coding gene	Chr11:76416121-76440627 (+)
A/J	MGP_AJ_G0018686	protein coding gene	Chr11:73568576-73591967 (+)
AKR/J	MGP_AKRJ_G0018656	protein coding gene	Chr11:75795155-75818638 (+)
BALB/cJ	MGP_BALBcJ_G0018660	protein coding gene	Chr11:73948546-73972706 (+)
C3H/HeJ	MGP_C3HHeJ_G0018473	protein coding gene	Chr11:75814090-75838438 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019111	protein coding gene	Chr11:78829044-78859268 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016746	protein coding gene	Chr11:70581232-70604565 (+)
CAST/EiJ	MGP_CASTEiJ_G0018027	protein coding gene	Chr11:76208986-76232878 (+)
CBA/J	MGP_CBAJ_G0018443	protein coding gene	Chr11:82278561-82304100 (+)
DBA/2J	MGP_DBA2J_G0018552	protein coding gene	Chr11:73172131-73196235 (+)
FVB/NJ	MGP_FVBNJ_G0018542	protein coding gene	Chr11:72735466-72759336 (+)
LP/J	MGP_LPJ_G0018623	protein coding gene	Chr11:76999207-77023000 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018568	protein coding gene	Chr11:82816290-82841715 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019151	protein coding gene	Chr11:76012338-76036079 (+)
PWK/PhJ	MGP_PWKPhJ_G0017798	protein coding gene	Chr11:73878938-73903157 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017589	protein coding gene	Chr11:75563877-75587541 (+)
WSB/EiJ	MGP_WSBEiJ_G0018080	protein coding gene	Chr11:75823415-75848856 (+)

Human Ortholog

MYO1C, myosin IC

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO1C, myosin IC
Synonyms

MMIb, MMI-beta, MyoIC, myr2, NMI
Links

HGNC:7597

NCBI Gene ID: 4641

neXtProt AC: NX_O00159

UniProt: O00159
Chr Location

17p13.3; chr17:1464186-1492686 (-) GRCh38

MGI Vertebrate Homology

Myo1c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYO1C
Gene Tree

Myo1c

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

16
Targeted

8
Genomic Mutations

2 involving Myo1c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

87 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in (Y61G) mutation that sensitizes to N6-modified ADP analogs display altered fast adaption in vestibular hair cells. Mice homozygous for a nuclear isoform-specifc knock-out allele exhibit minor changes in bone marrow density and red blood cells.

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All GO Annotations

79
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

7
cDNA Data

228
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo1c

ZFIN myo1ca, myo1cb

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All Sequences

75
RefSeq

8
UniProt

2
CCDS

CCDS25054.1, CCDS36228.1, CCDS88191.1

Ensembl

ENSMUSG00000017774 (Evidence)
NCBI Gene

17913

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017774	Ensembl Gene Model \| MGI Sequence Detail	23407	C57BL/6J	± kb
transcript	ENSMUST00000102505	Ensembl \| MGI Sequence Detail	4652	Not Applicable
polypeptide	ENSMUSP00000099563	Ensembl \| MGI Sequence Detail	1063	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010857 myosin-Ic

(term hierarchy)
PDB

4R8G
InterPro Domains

IPR036072 Class I myosin, motor domain

IPR010926 Class I myosin tail homology domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q9WTI7 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 235

Genomic 4

cDNA 229

Primer pair 1

Other 1

Microarray probesets 6

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MGD-MRK-35069, MGI:2144662

Summaries

All 82

Developmental Gene Expression 2

Gene Ontology 19

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Myo1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3578	Chr11:75541314-75541319 (+)	-13 bp
Tssr103017	Chr11:75541327-75541370 (+)	19 bp
Tssr103018	Chr11:75541379-75541396 (+)	58 bp
Tssr103019	Chr11:75541438-75541450 (+)	114 bp
Tssr103020	Chr11:75542025-75542036 (+)	701 bp
Tssr103021	Chr11:75542047-75542072 (+)	730 bp
Tssr103022	Chr11:75542330-75542363 (+)	1,017 bp
Tssr103023	Chr11:75542367-75542439 (+)	1,073 bp
Tssr103024	Chr11:75542445-75542463 (+)	1,124 bp
Tssr103025	Chr11:75543027-75543068 (+)	1,718 bp
Tssr103026	Chr11:75546577-75546601 (+)	5,259 bp
Tssr103027	Chr11:75546671-75546682 (+)	5,347 bp
Tssr103028	Chr11:75546737-75546744 (+)	5,411 bp
Tssr103029	Chr11:75546754-75546763 (+)	5,429 bp
Tssr103030	Chr11:75546805-75546826 (+)	5,486 bp
Tssr103031	Chr11:75546829-75546863 (+)	5,516 bp
Tssr103032	Chr11:75546929-75547003 (+)	5,636 bp
Tssr103033	Chr11:75552440-75552449 (+)	11,115 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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