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Efna3 Gene Detail
Summary
  • Symbol
    Efna3
  • Name
    ephrin A3
  • Synonyms
    EFL-2, Ehk1-L, Epl3, LERK-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106644
    NCBI Gene: 13638
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89221206-89230272 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106644
 protein coding gene Chr3:89221200-89231359 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027430
 protein coding gene Chr3:89523309-89532375 (-)
A/J MGP_AJ_G0027394
 protein coding gene Chr3:86560293-86569372 (-)
AKR/J MGP_AKRJ_G0027358
 protein coding gene Chr3:88651550-88660627 (-)
BALB/cJ MGP_BALBcJ_G0027403
 protein coding gene Chr3:86526457-86535531 (-)
C3H/HeJ MGP_C3HHeJ_G0027145
 protein coding gene Chr3:88855975-88865054 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027849
 protein coding gene Chr3:92909250-92918314 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025201
 protein coding gene Chr3:82043584-82052826 (-)
CAST/EiJ MGP_CASTEiJ_G0026591
 protein coding gene Chr3:89212398-89221508 (-)
CBA/J MGP_CBAJ_G0027119
 protein coding gene Chr3:96089934-96099001 (-)
DBA/2J MGP_DBA2J_G0027257
 protein coding gene Chr3:85938143-85947207 (-)
FVB/NJ MGP_FVBNJ_G0027225
 protein coding gene Chr3:84280205-84289284 (-)
LP/J MGP_LPJ_G0027366
 protein coding gene Chr3:90600706-90609755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027245
 protein coding gene Chr3:102305535-102315777 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027908
 protein coding gene Chr3:88406052-88415131 (-)
PWK/PhJ MGP_PWKPhJ_G0026325
 protein coding gene Chr3:85814557-85823734 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026144
 protein coding gene Chr3:87573690-87582738 (-)
WSB/EiJ MGP_WSBEiJ_G0026673
 protein coding gene Chr3:88800721-88810041 (-)



Homology
more
  • Human Ortholog
    EFNA3, ephrin A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNA3, ephrin A3
  • Synonyms
    EFL2, Ehk1-L, EPLG3, LERK3
  • Links
    NCBI Gene ID: 1944
    neXtProt AC: NX_P52797
    UniProt: P52797

  • Chr Location
    1q21.3; chr1:155078837-155087538 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit disorganised and elongated dendritic spine of CA1 pyramidal neuron and reduced hippocampal-dependent learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    206
  • cDNA Data
    13
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028039 Ensembl Gene Model | MGI Sequence Detail 9067 C57BL/6J ±  kb
    transcript ENSMUST00000029673 Ensembl | MGI Sequence Detail 2363 Not Applicable  
    polypeptide ENSMUSP00000029673 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 15
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35101, MGI:2139989
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 43
      Diseases 2
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:32841 Cerretti DP, et al., The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996 Apr 15;33(2):277-82
    • Latest
      J:355410 Arpke RW, et al., Normal muscle fiber type distribution is recapitulated in aged ephrin-A3(-/-) mice that previously lacked most slow myofibers. Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C718-C727
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory