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Enpep Gene Detail
Summary
  • Symbol
    Enpep
  • Name
    glutamyl aminopeptidase
  • Synonyms
    6030431M22Rik, aminopeptidase-A, APA, Bp-1/6C3, Ly-51, Ly51
  • Feature Type
    protein coding gene
  • IDs
    MGI:106645
    NCBI Gene: 13809
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129062824-129126369 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 57.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1958 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106645
 protein coding gene Chr3:129062824-129126398 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027869
 protein coding gene Chr3:131908131-131977627 (-)
A/J MGP_AJ_G0027827
 protein coding gene Chr3:127334075-127397923 (-)
AKR/J MGP_AKRJ_G0027792
 protein coding gene Chr3:130626937-130692196 (-)
BALB/cJ MGP_BALBcJ_G0027840
 protein coding gene Chr3:127175852-127239217 (-)
C3H/HeJ MGP_C3HHeJ_G0027569
 protein coding gene Chr3:131019195-131087850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028284
 protein coding gene Chr3:136635538-136713134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025622
 protein coding gene Chr3:122867470-122933013 (-)
CAST/EiJ MGP_CASTEiJ_G0027026
 protein coding gene Chr3:130662267-130734533 (-)
CBA/J MGP_CBAJ_G0027545
 protein coding gene Chr3:141229711-141299736 (-)
DBA/2J MGP_DBA2J_G0027686
 protein coding gene Chr3:126527925-126592435 (-)
FVB/NJ MGP_FVBNJ_G0027653
 protein coding gene Chr3:124104450-124169685 (-)
LP/J MGP_LPJ_G0027795
 protein coding gene Chr3:133422392-133491209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027684
 protein coding gene Chr3:149199561-149268700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028341
 protein coding gene Chr3:130289866-130359102 (-)
PWK/PhJ MGP_PWKPhJ_G0026750
 protein coding gene Chr3:126256252-126320267 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026575
 protein coding gene Chr3:128351237-128419467 (-)
WSB/EiJ MGP_WSBEiJ_G0027105
 protein coding gene Chr3:130999408-131066706 (-)



Homology
more
  • Human Ortholog
    ENPEP, glutamyl aminopeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPEP, glutamyl aminopeptidase
  • Synonyms
    APA, CD249, gp160
  • Links
    NCBI Gene ID: 2028
    neXtProt AC: NX_Q07075
    UniProt: Q07075

  • Chr Location
    4q25; chr4:110365733-110565285 (+)  GRCh38
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and morphologically unaffected with normal B and T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    70
  • cDNA Data
    85
  • Literature Summary
    22
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028024 Ensembl Gene Model | MGI Sequence Detail 63546 C57BL/6J ±  kb
transcript ENSMUST00000029658 Ensembl | MGI Sequence Detail 4181 Not Applicable  
polypeptide ENSMUSP00000029658 Ensembl | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002039 glutamyl aminopeptidase
    (term hierarchy)
  • EC
    3.4.11.-, 3.4.11.7
  • InterPro Domains
    IPR045357 Aminopeptidase N-like , N-terminal domain
    IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
    IPR034016 Aminopeptidase N-type
    IPR024571 ERAP1-like C-terminal domain
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR050344 Peptidase M1 family aminopeptidases
    IPR014782 Peptidase M1, membrane alanine aminopeptidase
    IPR027268 Peptidase M4/M1, CTD superfamily
  • GlyGen
    P16406 10 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 99
    Genomic 11
    cDNA 85
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11994, MGD-MRK-12038, MGD-MRK-1610, MGD-MRK-35102, MGI:2443313
References
more
  • Summaries
    All 76
    Developmental Gene Expression 22
    Diseases 1
    Gene Ontology 11
    Phenotypes 19
  • Earliest
    J:10285 Wu Q, et al., Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci U S A. 1990 Feb;87(3):993-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory