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Ly6e Gene Detail
Summary
  • Symbol
    Ly6e
  • Name
    lymphocyte antigen 6 family member E
  • Synonyms
    9804, Ly67, RIG-E, Sca-2, Tsa1, TSA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106651
    NCBI Gene: 17069
  • Member of
    Ly6 cluster
  • Alliance
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74826900-74831752 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106651
protein coding gene Chr15:74826874-74831753 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021945
protein coding gene Chr15:74772380-74777234 (+)
A/J MGP_AJ_G0021902
protein coding gene Chr15:72090723-72096222 (+)
AKR/J MGP_AKRJ_G0021886
protein coding gene Chr15:73989411-73994259 (+)
BALB/cJ MGP_BALBcJ_G0021911
protein coding gene Chr15:72108624-72113677 (+)
C3H/HeJ MGP_C3HHeJ_G0021684
protein coding gene Chr15:74092192-74097250 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022351
protein coding gene Chr15:77589280-77594134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019886
protein coding gene Chr15:68460179-68465039 (+)
CAST/EiJ MGP_CASTEiJ_G0021203
protein coding gene Chr15:74912553-74917406 (+)
CBA/J MGP_CBAJ_G0021650
protein coding gene Chr15:80122421-80128837 (+)
DBA/2J MGP_DBA2J_G0021775
protein coding gene Chr15:71702331-71707185 (+)
FVB/NJ MGP_FVBNJ_G0021757
protein coding gene Chr15:70722703-70727557 (+)
LP/J MGP_LPJ_G0021847
protein coding gene Chr15:74856562-74861416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021780
protein coding gene Chr15:85438304-85453376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022372
protein coding gene Chr15:74327951-74334619 (+)
PWK/PhJ MGP_PWKPhJ_G0020944
protein coding gene Chr15:71802822-71807662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020784
protein coding gene Chr15:74180427-74185272 (+)
WSB/EiJ MGP_WSBEiJ_G0021255
protein coding gene Chr15:74356096-74360959 (+)



Homology
more
  • Human Ortholog
    LY6E, lymphocyte antigen 6 family member E
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY6E, lymphocyte antigen 6 family member E
  • Synonyms
    RIG-E, RIGE, SCA-2, SCA2, TSA-1
  • Links
    NCBI Gene ID: 4061
    neXtProt AC: NX_Q16553
    UniProt: Q16553

  • Chr Location
    8q24.3; chr8:143017982-143023832 (+)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos as a result of heart defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022587 Ensembl Gene Model | MGI Sequence Detail 4853 C57BL/6J ±  kb
    transcript ENSMUST00000187284 Ensembl | MGI Sequence Detail 1801 Not Applicable  
    polypeptide ENSMUSP00000140553 Ensembl | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 899
      Genomic 1
      cDNA 893
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15264, MGD-MRK-35109
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory