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Epcam Gene Detail
Summary
  • Symbol
    Epcam
  • Name
    epithelial cell adhesion molecule
  • Synonyms
    CD326, EGP-2, Egp314, Ep-CAM, EpCAM, EpCAM1, GA733-2, gp40, Ly74, panepithelial glycoprotein 314, Tacstd1, TROP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106653
    NCBI Gene: 17075
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:87943407-87958555 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 57.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    597 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106653
 protein coding gene Chr17:87943407-87958557 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024104
 protein coding gene Chr17:91055272-91073600 (+)
A/J MGP_AJ_G0024063
 protein coding gene Chr17:88120103-88135750 (+)
AKR/J MGP_AKRJ_G0024032
 protein coding gene Chr17:89597454-89614660 (+)
BALB/cJ MGP_BALBcJ_G0024064
 protein coding gene Chr17:87962248-87977297 (+)
C3H/HeJ MGP_C3HHeJ_G0023829
 protein coding gene Chr17:90480923-90497534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024509
 protein coding gene Chr17:94193752-94209609 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021948
 protein coding gene Chr17:83244004-83262132 (+)
CAST/EiJ MGP_CASTEiJ_G0023308
 protein coding gene Chr17:91308522-91324565 (+)
CBA/J MGP_CBAJ_G0023803
 protein coding gene Chr17:98186102-98202718 (+)
DBA/2J MGP_DBA2J_G0023931
 protein coding gene Chr17:86538113-86553592 (+)
FVB/NJ MGP_FVBNJ_G0023897
 protein coding gene Chr17:86058859-86075695 (+)
LP/J MGP_LPJ_G0024015
 protein coding gene Chr17:91849902-91867063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023925
 protein coding gene Chr17:98019290-98035882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024554
 protein coding gene Chr17:90133795-90148608 (+)
PWK/PhJ MGP_PWKPhJ_G0023053
 protein coding gene Chr17:86202567-86218208 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022864
 protein coding gene Chr17:86865946-86882993 (+)
WSB/EiJ MGP_WSBEiJ_G0023374
 protein coding gene Chr17:90959887-90977802 (+)



Homology
more
  • Human Ortholog
    EPCAM, epithelial cell adhesion molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPCAM, epithelial cell adhesion molecule
  • Synonyms
    Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, LYNCH8, M4S1, MIC18, MK-1, MOC-31, TACSTD1, TROP1
  • Links
    NCBI Gene ID: 4072
    neXtProt AC: NX_P16422
    UniProt: P16422

  • Chr Location
    2p21; chr2:47345158-47387601 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Epcam mouse models; 2 with human EPCAM associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 6 alleles in 4 genetic backgrounds
    7 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis with decreased embryo size, impaired labyrinth layer development and decreased number of trophoblast giant cells. Mice homozygous for another knock-out allele exhibit impaired intestinal tight junctions with lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1250
  • Tissues
    245
  • cDNA Data
    414
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17075 NCBI Gene Model | MGI Sequence Detail 15149 C57BL/6J ±  kb
    transcript NM_008532 RefSeq | MGI Sequence Detail 2061 C57BL/6  
    polypeptide Q99JW5 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 424
      Genomic 1
      cDNA 414
      Primer pair 6
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35111, MGD-MRK-35182
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 121
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:10429 Timblin C, et al., Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells. Nucleic Acids Res. 1990 Mar 25;18(6):1587-93
    • Latest
      J:355654 Cai S, et al., Single-cell transcriptome and chromatin accessibility mapping of upper lip and primary palate fusion. J Cell Mol Med. 2024 Oct;28(19):e70128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory