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Nap1l2 Gene Detail
Summary
  • Symbol
    Nap1l2
  • Name
    nucleosome assembly protein 1-like 2
  • Synonyms
    Bpx
  • Feature Type
    protein coding gene
  • IDs
    MGI:106654
    NCBI Gene: 17954
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:102227782-102230246 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 45.97 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106654
 protein coding gene ChrX:102227782-102230259 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035981
 protein coding gene ChrX:99791402-99793866 (-)
A/J MGP_AJ_G0035962
 protein coding gene ChrX:99736220-99738684 (-)
AKR/J MGP_AKRJ_G0035880
 protein coding gene ChrX:102751038-102753502 (-)
BALB/cJ MGP_BALBcJ_G0035951
 protein coding gene ChrX:98538648-98541112 (-)
C3H/HeJ MGP_C3HHeJ_G0035657
 protein coding gene ChrX:100266686-100269150 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036478
 protein coding gene ChrX:102740236-102742700 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033306
 protein coding gene ChrX:97396785-97399254 (-)
CAST/EiJ MGP_CASTEiJ_G0034944
 protein coding gene ChrX:84535784-84538248 (-)
CBA/J MGP_CBAJ_G0035633
 protein coding gene ChrX:105939946-105942410 (-)
DBA/2J MGP_DBA2J_G0035787
 protein coding gene ChrX:98985394-98987858 (-)
FVB/NJ MGP_FVBNJ_G0035727
 protein coding gene ChrX:98308680-98311144 (-)
LP/J MGP_LPJ_G0035879
 protein coding gene ChrX:100824433-100826897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035760
 protein coding gene ChrX:110570371-110572835 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036504
 protein coding gene ChrX:99492484-99494948 (-)
PWK/PhJ MGP_PWKPhJ_G0034642
 protein coding gene ChrX:82128919-82131383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034470
 protein coding gene ChrX:85226852-85229319 (-)
WSB/EiJ MGP_WSBEiJ_G0035084
 protein coding gene ChrX:98228314-98230778 (-)



Homology
more
  • Human Ortholog
    NAP1L2, nucleosome assembly protein 1 like 2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAP1L2, nucleosome assembly protein 1 like 2
  • Synonyms
    BPX
  • Links
    NCBI Gene ID: 4674
    neXtProt AC: NX_Q9ULW6
    UniProt: Q9ULW6

  • Chr Location
    Xq13.2; chrX:73212299-73214851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Chimeric embryos with high contribution from heterozygous or homozygous null mutant ES cells exhibit severely abnormal neural tube development and die by embryonic day 14 (E14).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    12
  • cDNA Data
    15
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000082229 Ensembl Gene Model | MGI Sequence Detail 2465 C57BL/6J ±  kb
transcript ENSMUST00000121720 Ensembl | MGI Sequence Detail 2465 Not Applicable  
polypeptide ENSMUSP00000112677 Ensembl | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 5
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32160, MGD-MRK-35112
References
more
  • Summaries
    All 31
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:30901 Rougeulle C, et al., Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. Hum Mol Genet. 1996 Jan;5(1):41-9
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory