Adra1d MGI Mouse Gene Detail - MGI:106673 - adrenergic receptor, alpha 1d

Symbol

Adra1d
Name

adrenergic receptor, alpha 1d
Synonyms

Adra-1, Adra1, Adra1a, alpha1D-AR, Gpcr8

Feature Type

protein coding gene
IDs

MGI:106673
NCBI Gene: 11550
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:131387770-131404203 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.50 cM
Mapping Data

6 experiments

SNPs within 2kb

573 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106673	protein coding gene	Chr2:131387277-131404417 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026532	protein coding gene	Chr2:135087660-135104132 (-)
A/J	MGP_AJ_G0026496	protein coding gene	Chr2:129595853-129612279 (-)
AKR/J	MGP_AKRJ_G0026471	protein coding gene	Chr2:133329442-133345892 (-)
BALB/cJ	MGP_BALBcJ_G0026508	protein coding gene	Chr2:129984861-130001298 (-)
C3H/HeJ	MGP_C3HHeJ_G0026251	protein coding gene	Chr2:133792647-133809109 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026953	protein coding gene	Chr2:139224563-139241004 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024330	protein coding gene	Chr2:124332475-124348695 (-)
CAST/EiJ	MGP_CASTEiJ_G0025712	protein coding gene	Chr2:134064192-134080513 (-)
CBA/J	MGP_CBAJ_G0026231	protein coding gene	Chr2:144417967-144434435 (-)
DBA/2J	MGP_DBA2J_G0026365	protein coding gene	Chr2:128986705-129003036 (-)
FVB/NJ	MGP_FVBNJ_G0026329	protein coding gene	Chr2:127613137-127630575 (-)
LP/J	MGP_LPJ_G0026470	protein coding gene	Chr2:135308469-135324924 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026349	protein coding gene	Chr2:148231241-148247649 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027008	protein coding gene	Chr2:133312783-133329251 (-)
PWK/PhJ	MGP_PWKPhJ_G0025448	protein coding gene	Chr2:128569147-128585544 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025250	protein coding gene	Chr2:132470174-132486660 (-)
WSB/EiJ	MGP_WSBEiJ_G0025786	protein coding gene	Chr2:134218944-134235571 (-)

Human Ortholog

ADRA1D, adrenoceptor alpha 1D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADRA1D, adrenoceptor alpha 1D
Synonyms

ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
Links

HGNC:280

NCBI Gene ID: 146

neXtProt AC: NX_P25100

UniProt: P25100
Chr Location

20p13; chr20:4220630-4249287 (-) GRCh38

MGI Vertebrate Homology

Adra1d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADRA1D
Gene Tree

Adra1d

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Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Adra1d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display hypotension or reduced rearing behavior in a novel environment, decreased wheel-running activity during the night, and reduced hyperlocomotion after amphetamine administration.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

12
cDNA Data

7
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adra1d

ZFIN adra1d

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All Sequences

28
RefSeq

2
UniProt

2
CCDS

CCDS16764.1

Ensembl

ENSMUSG00000027335 (Evidence)
NCBI Gene

11550

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027335	Ensembl Gene Model \| MGI Sequence Detail	16434	C57BL/6J	± kb
transcript	ENSMUST00000103184	Ensembl \| MGI Sequence Detail	1899	Not Applicable
polypeptide	ENSMUSP00000099473	Ensembl \| MGI Sequence Detail	562	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001185 alpha-1D adrenergic receptor

(term hierarchy)
InterPro Domains

IPR002233 Adrenoceptor family

IPR000363 Alpha 1D adrenoceptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P97714 2 sites

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All nucleic 15

Genomic 2

cDNA 9

Primer pair 2

Other 2

Microarray probesets 1

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MGD-MRK-1134, MGD-MRK-1139, MGD-MRK-16339, MGD-MRK-28037, MGD-MRK-35132, MGI:104746, MGI:99561

Summaries

All 69

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 23
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345649 Sandroni PB, et al., The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart. J Mol Cell Cardiol. 2024 Feb;187:101-117

TSS for Adra1d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26403	Chr2:131404675-131404693 (-)	-481 bp
Tssr26402	Chr2:131404435-131404455 (-)	-242 bp
Tssr26401	Chr2:131404408-131404422 (-)	-212 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24