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Adipoq Gene Detail
Summary
  • Symbol
    Adipoq
  • Name
    adiponectin, C1Q and collagen domain containing
  • Synonyms
    Acdc, Acrp30, Ad, adipo, adiponectin, apM1, APN, GBP28
  • Feature Type
    protein coding gene
  • IDs
    MGI:106675
    NCBI Gene: 11450
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22965286-22976718 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.96 cM, cytoband B3-B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106675
 protein coding gene Chr16:22965286-22976778 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022680
 protein coding gene Chr16:20712638-20724108 (+)
A/J MGP_AJ_G0022642
 protein coding gene Chr16:19717251-19729322 (+)
AKR/J MGP_AKRJ_G0022616
 protein coding gene Chr16:20559073-20577410 (+)
BALB/cJ MGP_BALBcJ_G0022647
 protein coding gene Chr16:19921980-19933110 (+)
C3H/HeJ MGP_C3HHeJ_G0022411
 protein coding gene Chr16:20676909-20689234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023096
 protein coding gene Chr16:21203019-21215045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020614
 protein coding gene Chr16:20350619-20363674 (+)
CAST/EiJ MGP_CASTEiJ_G0021940
 protein coding gene Chr16:20651127-20663417 (+)
CBA/J MGP_CBAJ_G0022382
 protein coding gene Chr16:22072446-22084934 (+)
DBA/2J MGP_DBA2J_G0022514
 protein coding gene Chr16:19675513-19686920 (+)
FVB/NJ MGP_FVBNJ_G0022490
 protein coding gene Chr16:19670430-19682444 (+)
LP/J MGP_LPJ_G0022582
 protein coding gene Chr16:20504601-20515676 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022509
 protein coding gene Chr16:21607738-21619391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023108
 protein coding gene Chr16:20509708-20522227 (+)
PWK/PhJ MGP_PWKPhJ_G0021679
 protein coding gene Chr16:19946992-19959266 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021510
 protein coding gene Chr16:20247352-20258672 (+)
WSB/EiJ MGP_WSBEiJ_G0021984
 protein coding gene Chr16:20462091-20474934 (+)



Homology
more
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADIPOQ, adiponectin, C1Q and collagen domain containing
  • Synonyms
    ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28
  • Links
    NCBI Gene ID: 9370
    neXtProt AC: NX_Q15848
    UniProt: Q15848

  • Chr Location
    3q27.3; chr3:186842704-186858463 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human ADIPOQ associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 7 alleles in 13 genetic backgrounds
    40 phenotypes from multigenic genotypes
    2 images
    274 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased beta-oxidation in muscle and liver, impaired free fatty acid clearance, and moderate insulin resistance. Heterozygotes show mild insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    158
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    48
  • cDNA Data
    72
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11450 NCBI Gene Model | MGI Sequence Detail 11433 C57BL/6J ±  kb
    transcript NM_009605 RefSeq | MGI Sequence Detail 1232 ZRU/MplStud  
    polypeptide Q60994 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 1
      cDNA 74
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35134
    References
    more
    • Summaries
      All 465
      Developmental Gene Expression 36
      Gene Ontology 38
      Phenotypes 274
    • Earliest
      J:32963 Scherer PE, et al., A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746-9
    • Latest
      J:354440 McClure JJ, et al., Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee. Osteoarthritis Cartilage. 2024 Aug 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory