Adgre1 Gene Detail

Summary

• Symbol
  Adgre1
• Name
  adhesion G protein-coupled receptor E1
• Synonyms
  DD7A5-7, EGF-TM7, Emr1, F4/80, Ly71, TM7LN3

• Feature Type
  protein coding gene
• IDs
  MGI:106912
  NCBI Gene: 13733
• Alliance
  gene page
• Transcription Start Sites
  116 TSS

Location &
Maps

• Sequence Map
  Chr17:57665691-57790527 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 29.80 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  2449 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106912	protein coding gene	Chr17:57665650-57790527 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023963	protein coding gene	Chr17:59147629-59269106 (+)
A/J	MGP_AJ_G0023921	protein coding gene	Chr17:57494076-57611781 (+)
AKR/J	MGP_AKRJ_G0023890	protein coding gene	Chr17:58219052-58342360 (+)
BALB/cJ	MGP_BALBcJ_G0023922	protein coding gene	Chr17:57337279-57447764 (+)
C3H/HeJ	MGP_C3HHeJ_G0023686	protein coding gene	Chr17:58940332-59068461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024368	protein coding gene	Chr17:61442445-61567913 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021814	protein coding gene	Chr17:53956828-54082874 (+)
CAST/EiJ	MGP_CASTEiJ_G0023168	protein coding gene	Chr17:59257968-59387157 (+)
CBA/J	MGP_CBAJ_G0023662	protein coding gene	Chr17:63847821-63985795 (+)
DBA/2J	MGP_DBA2J_G0023790	protein coding gene	Chr17:56181935-56294532 (+)
FVB/NJ	MGP_FVBNJ_G0023756	protein coding gene	Chr17:55760230-55882940 (+)
LP/J	MGP_LPJ_G0023872	protein coding gene	Chr17:59822175-59924870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023784	protein coding gene	Chr17:63254735-63374094 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024412	protein coding gene	Chr17:58584447-58719767 (+)
PWK/PhJ	MGP_PWKPhJ_G0022914	protein coding gene	Chr17:55556467-55657494 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022725	protein coding gene	Chr17:55363700-55491053 (+)
WSB/EiJ	MGP_WSBEiJ_G0023234	protein coding gene	Chr17:59226770-59328337 (+)

Homology

• Human Ortholog
  ADGRE1, adhesion G protein-coupled receptor E1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ADGRE1, adhesion G protein-coupled receptor E1
  
• Synonyms
  EMR1, TM7LN3
• Links
  HGNC:3336

  NCBI Gene ID: 2015

  neXtProt AC: NX_Q14246

  UniProt: Q14246

  
  
• Chr Location
  19p13.3-p13.2; chr19:6887566-6940459 (+)  GRCh38

---

• MGI Vertebrate Homology
  Adgre1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: ADGRE1
• Gene Tree
  Adgre1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 5 alleles in 5 genetic backgrounds
  23 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (ENU)
  4
• Endonuclease-mediated
  7
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  79 strains or lines available

Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  9

Expression

• Assay Results
  1160
• Tissues
  252
• cDNA Data
  41
• Literature Summary
  231

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase adgre1

Sequences &
Gene Models

• All Sequences
  67
• RefSeq
  10
• UniProt
  11
• CCDS
  CCDS50160.1

• Ensembl
  ENSMUSG00000004730 (Evidence)
• NCBI Gene
  13733

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000004730	Ensembl Gene Model | MGI Sequence Detail	124837	C57BL/6J
transcript	ENSMUST00000086763	Ensembl | MGI Sequence Detail	3238	Not Applicable
polypeptide	ENSMUSP00000083971	Ensembl | MGI Sequence Detail	931	Not Applicable

Protein
Information

• UniProt
  11 Sequences
• Protein Ontology
  PR:000001813 adhesion G protein-coupled receptor E1
  (term hierarchy)
• InterPro Domains
  IPR018097 EGF-like calcium-binding, conserved site
  IPR001881 EGF-like calcium-binding domain
  IPR000742 EGF-like domain
  IPR000152 EGF-type aspartate/asparagine hydroxylation site
  IPR050751 Extracellular matrix structural protein
  IPR046338 GAIN domain superfamily
  IPR001740 GPCR family 2, EMR1-like receptor
  IPR017981 GPCR, family 2-like, 7TM
  IPR000832 GPCR, family 2, secretin-like
  IPR017983 GPCR, family 2, secretin-like, conserved site
  IPR000203 GPS motif
  IPR009030 Growth factor receptor cysteine-rich domain superfamily
  IPR049883 NOTCH1 EGF-like calcium-binding domain
• GlyGen
  Q61549 10 sites, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 51

  cDNA 44

  Primer pair 6

  Other 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-32093, MGD-MRK-35122, MGD-MRK-35373, MGI:105054, MGI:106663

References

• Summaries
  All 298

  Developmental Gene Expression 231

  Gene Ontology 9

  Phenotypes 23
• Earliest
  J:18061 Chen HL, et al., Gestation-related expression of the interferon-gamma receptor gene in mouse uterine and embryonic hematopoietic cells. J Leukoc Biol. 1994 May;55(5):617-25
• Latest
  J:352032 Wang L, et al., ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience. 2024 Jul 19;27(7):110273

TSS for Adgre1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145405	Chr17:57665572-57665591 (+)	-109 bp
Tssr145406	Chr17:57665682-57665723 (+)	12 bp
Tssr145407	Chr17:57667433-57667462 (+)	1,757 bp
Tssr145408	Chr17:57668043-57668056 (+)	2,359 bp
Tssr145409	Chr17:57668159-57668172 (+)	2,475 bp
Tssr145410	Chr17:57668692-57668701 (+)	3,006 bp
Tssr145411	Chr17:57669428-57669445 (+)	3,746 bp
Tssr145412	Chr17:57669553-57669564 (+)	3,868 bp
Tssr145413	Chr17:57669611-57669641 (+)	3,935 bp
Tssr145414	Chr17:57669653-57669662 (+)	3,967 bp
Tssr145415	Chr17:57669677-57669689 (+)	3,992 bp
Tssr145416	Chr17:57669694-57669707 (+)	4,010 bp
Tssr145417	Chr17:57669741-57669796 (+)	4,078 bp
Tssr145418	Chr17:57669887-57669898 (+)	4,202 bp
Tssr145419	Chr17:57670295-57670326 (+)	4,620 bp
Tssr145420	Chr17:57674090-57674102 (+)	8,405 bp
Tssr145421	Chr17:57674200-57674232 (+)	8,525 bp
Tssr145422	Chr17:57674291-57674314 (+)	8,612 bp
Tssr145423	Chr17:57674337-57674381 (+)	8,668 bp
Tssr145424	Chr17:57674417-57674451 (+)	8,743 bp
Tssr145425	Chr17:57674460-57674471 (+)	8,775 bp
Tssr145426	Chr17:57674552-57674613 (+)	8,892 bp
Tssr145427	Chr17:57674626-57674634 (+)	8,939 bp
Tssr145428	Chr17:57674668-57674740 (+)	9,013 bp
Tssr145429	Chr17:57682980-57682991 (+)	17,295 bp
Tssr145430	Chr17:57683016-57683033 (+)	17,334 bp
Tssr145431	Chr17:57683360-57683372 (+)	17,675 bp
Tssr145432	Chr17:57684118-57684135 (+)	18,436 bp
Tssr145433	Chr17:57684234-57684245 (+)	18,549 bp
Tssr145434	Chr17:57684435-57684446 (+)	18,750 bp
Tssr145435	Chr17:57684571-57684588 (+)	18,889 bp
Tssr145436	Chr17:57684609-57684620 (+)	18,924 bp
Tssr145437	Chr17:57684625-57684636 (+)	18,940 bp
Tssr145438	Chr17:57684688-57684699 (+)	19,003 bp
Tssr145439	Chr17:57692044-57692056 (+)	26,359 bp
Tssr145440	Chr17:57693611-57693625 (+)	27,927 bp
Tssr145441	Chr17:57693642-57693653 (+)	27,957 bp
Tssr145442	Chr17:57693670-57693686 (+)	27,987 bp
Tssr145443	Chr17:57693709-57693722 (+)	28,025 bp
Tssr145444	Chr17:57696130-57696138 (+)	30,443 bp
Tssr145445	Chr17:57705581-57705623 (+)	39,911 bp
Tssr145446	Chr17:57708149-57708160 (+)	42,464 bp
Tssr145447	Chr17:57708170-57708205 (+)	42,497 bp
Tssr145448	Chr17:57709534-57709546 (+)	43,849 bp
Tssr145449	Chr17:57709562-57709618 (+)	43,899 bp
Tssr145450	Chr17:57709756-57709822 (+)	44,098 bp
Tssr145451	Chr17:57709825-57709838 (+)	44,141 bp
Tssr145452	Chr17:57709856-57709872 (+)	44,173 bp
Tssr145453	Chr17:57711440-57711446 (+)	45,752 bp
Tssr145454	Chr17:57712271-57712291 (+)	46,590 bp
Tssr145455	Chr17:57713831-57713919 (+)	48,184 bp
Tssr145456	Chr17:57713939-57713952 (+)	48,255 bp
Tssr145457	Chr17:57713975-57714000 (+)	48,297 bp
Tssr145458	Chr17:57715339-57715468 (+)	49,713 bp
Tssr145459	Chr17:57715607-57715650 (+)	49,938 bp
Tssr145460	Chr17:57717769-57717827 (+)	52,107 bp
Tssr145461	Chr17:57718286-57718311 (+)	52,608 bp
Tssr145462	Chr17:57718967-57718983 (+)	53,284 bp
Tssr145463	Chr17:57719037-57719049 (+)	53,352 bp
Tssr145464	Chr17:57719187-57719222 (+)	53,514 bp
Tssr145465	Chr17:57719293-57719305 (+)	53,608 bp
Tssr145466	Chr17:57719327-57719336 (+)	53,641 bp
Tssr145467	Chr17:57719347-57719373 (+)	53,669 bp
Tssr145468	Chr17:57719401-57719424 (+)	53,722 bp
Tssr145469	Chr17:57719512-57719525 (+)	53,828 bp
Tssr145476	Chr17:57723615-57723617 (+)	57,925 bp
Tssr145477	Chr17:57724501-57724516 (+)	58,818 bp
Tssr145478	Chr17:57726304-57726375 (+)	60,649 bp
Tssr145479	Chr17:57726402-57726420 (+)	60,720 bp
Tssr145480	Chr17:57727406-57727419 (+)	61,722 bp
Tssr145481	Chr17:57727557-57727571 (+)	61,873 bp
Tssr145482	Chr17:57727841-57727862 (+)	62,161 bp
Tssr145483	Chr17:57728665-57728678 (+)	62,981 bp
Tssr145484	Chr17:57728691-57728702 (+)	63,006 bp
Tssr145485	Chr17:57731877-57731888 (+)	66,192 bp
Tssr145486	Chr17:57732119-57732148 (+)	66,443 bp
Tssr145487	Chr17:57745376-57745425 (+)	79,710 bp
Tssr145488	Chr17:57748317-57748349 (+)	82,642 bp
Tssr145489	Chr17:57752023-57752035 (+)	86,338 bp
Tssr145490	Chr17:57752060-57752076 (+)	86,377 bp
Tssr145491	Chr17:57752081-57752094 (+)	86,397 bp
Tssr145492	Chr17:57754819-57754906 (+)	89,172 bp
Tssr145493	Chr17:57756857-57756915 (+)	91,195 bp
Tssr145494	Chr17:57758355-57758380 (+)	92,677 bp
Tssr145495	Chr17:57758399-57758423 (+)	92,720 bp
Tssr145496	Chr17:57758495-57758510 (+)	92,812 bp
Tssr145497	Chr17:57758595-57758609 (+)	92,911 bp
Tssr145498	Chr17:57758612-57758627 (+)	92,929 bp
Tssr145499	Chr17:57760507-57760529 (+)	94,827 bp
Tssr145500	Chr17:57762866-57762890 (+)	97,187 bp
Tssr145501	Chr17:57765885-57765897 (+)	100,200 bp
Tssr145502	Chr17:57766918-57766949 (+)	101,243 bp
Tssr145503	Chr17:57767001-57767016 (+)	101,318 bp
Tssr145504	Chr17:57767026-57767036 (+)	101,340 bp
Tssr145505	Chr17:57767042-57767082 (+)	101,371 bp
Tssr145506	Chr17:57767709-57767730 (+)	102,029 bp
Tssr145507	Chr17:57769760-57769778 (+)	104,078 bp
Tssr145508	Chr17:57769898-57769913 (+)	104,215 bp
Tssr145509	Chr17:57770367-57770391 (+)	104,688 bp
Tssr145510	Chr17:57773243-57773256 (+)	107,559 bp
Tssr145511	Chr17:57773308-57773323 (+)	107,625 bp
Tssr145512	Chr17:57773682-57773722 (+)	108,011 bp
Tssr145513	Chr17:57774300-57774316 (+)	108,617 bp
Tssr145514	Chr17:57774385-57774397 (+)	108,700 bp
Tssr145515	Chr17:57779560-57779579 (+)	113,879 bp
Tssr145516	Chr17:57783152-57783213 (+)	117,492 bp
Tssr145517	Chr17:57783295-57783315 (+)	117,614 bp
Tssr145518	Chr17:57783322-57783358 (+)	117,649 bp
Tssr145519	Chr17:57783401-57783425 (+)	117,722 bp
Tssr145520	Chr17:57783659-57783675 (+)	117,976 bp
Tssr145521	Chr17:57783678-57783708 (+)	118,002 bp
Tssr145522	Chr17:57783795-57783816 (+)	118,115 bp
Tssr145523	Chr17:57784206-57784218 (+)	118,521 bp
Tssr145524	Chr17:57784238-57784258 (+)	118,557 bp
Tssr145525	Chr17:57784299-57784331 (+)	118,624 bp
Tssr145526	Chr17:57785896-57785914 (+)	120,214 bp