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Msra Gene Detail
Summary
  • Symbol
    Msra
  • Name
    methionine sulfoxide reductase A
  • Synonyms
    2310045J23Rik, 6530413P12Rik, MSR-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:106916
    NCBI Gene: 110265
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64360074-64693352 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7035 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106916
 protein coding gene Chr14:64360070-64693352 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021472
 protein coding gene Chr14:58687825-59026206 (-)
A/J MGP_AJ_G0021431
 protein coding gene Chr14:57338568-57674120 (-)
AKR/J MGP_AKRJ_G0021407
 protein coding gene Chr14:59365305-59708762 (-)
BALB/cJ MGP_BALBcJ_G0021437
 protein coding gene Chr14:57294320-57629092 (-)
C3H/HeJ MGP_C3HHeJ_G0021214
 protein coding gene Chr14:58995335-59339206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021876
 protein coding gene Chr14:61425481-61781060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019416
 protein coding gene Chr14:55270647-55611056 (-)
CAST/EiJ MGP_CASTEiJ_G0020731
 protein coding gene Chr14:55449471-55800866 (-)
CBA/J MGP_CBAJ_G0021181
 protein coding gene Chr14:63287551-63643381 (-)
DBA/2J MGP_DBA2J_G0021304
 protein coding gene Chr14:57011803-57344191 (-)
FVB/NJ MGP_FVBNJ_G0021283
 protein coding gene Chr14:56400441-56738317 (-)
LP/J MGP_LPJ_G0021379
 protein coding gene Chr14:59722391-60060130 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021312
 protein coding gene Chr14:62467101-62819570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021899
 protein coding gene Chr14:58526575-58870169 (-)
PWK/PhJ MGP_PWKPhJ_G0020475
 protein coding gene Chr14:53687990-54026919 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020308
 protein coding gene Chr14:54488003-54830883 (-)
WSB/EiJ MGP_WSBEiJ_G0020784
 protein coding gene Chr14:58843124-59185303 (-)



Homology
more
  • Human Ortholog
    MSRA, methionine sulfoxide reductase A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSRA, methionine sulfoxide reductase A
  • Synonyms
    PMSR
  • Links
    NCBI Gene ID: 4482
    neXtProt AC: NX_Q9UJ68
    UniProt: Q9UJ68

  • Chr Location
    8p23.1; chr8:10054292-10428891 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this allele display an increased sensitivity to oxidative stress, reductions in related enzyme levels, and reduced life spans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    99
  • cDNA Data
    58
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054733 Ensembl Gene Model | MGI Sequence Detail 333279 C57BL/6J ±  kb
transcript ENSMUST00000067927 Ensembl | MGI Sequence Detail 1860 Not Applicable  
polypeptide ENSMUSP00000065754 Ensembl | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 58
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35377, MGI:1914949, MGI:1923458
References
more
  • Summaries
    All 83
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 45
  • Earliest
    J:33347 Moskovitz J, et al., Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3205-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory