Tmpo MGI Mouse Gene Detail - MGI:106920

Symbol

Tmpo
Name

thymopoietin
Synonyms

5630400D24Rik, lamina-associated polypeptide 2, LAP2, TP

Feature Type

protein coding gene
IDs

MGI:106920
NCBI Gene: 21917
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:90983433-91017177 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 45.66 cM
Mapping Data

4 experiments

SNPs within 2kb

833 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106920	protein coding gene	Chr10:90983433-91017614 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017645	protein coding gene	Chr10:92441132-92465142 (-)
A/J	MGP_AJ_G0017624	protein coding gene	Chr10:89233023-89257037 (-)
AKR/J	MGP_AKRJ_G0017582	protein coding gene	Chr10:91794773-91818788 (-)
BALB/cJ	MGP_BALBcJ_G0017587	protein coding gene	Chr10:89517975-89541982 (-)
C3H/HeJ	MGP_C3HHeJ_G0017410	protein coding gene	Chr10:91813320-91837361 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018044	protein coding gene	Chr10:95496589-95520636 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015726	protein coding gene	Chr10:84900462-84924324 (-)
CAST/EiJ	MGP_CASTEiJ_G0016975	protein coding gene	Chr10:91741457-91767375 (-)
CBA/J	MGP_CBAJ_G0017379	protein coding gene	Chr10:99452831-99480278 (-)
DBA/2J	MGP_DBA2J_G0017485	protein coding gene	Chr10:88356674-88380687 (-)
FVB/NJ	MGP_FVBNJ_G0017477	protein coding gene	Chr10:87576077-87600084 (-)
LP/J	MGP_LPJ_G0017559	protein coding gene	Chr10:93075346-93101123 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017508	protein coding gene	Chr10:100897700-100921640 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018081	protein coding gene	Chr10:91683932-91707967 (-)
PWK/PhJ	MGP_PWKPhJ_G0016756	protein coding gene	Chr10:88416139-88440168 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016544	protein coding gene	Chr10:90438893-90462919 (-)
WSB/EiJ	MGP_WSBEiJ_G0017034	protein coding gene	Chr10:91655572-91679709 (-)

Human Ortholog

TMPO, thymopoietin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMPO, thymopoietin
Synonyms

CMD1T, LAP2, LEMD4, PRO0868, TP
Links

HGNC:11875

NCBI Gene ID: 7112

neXtProt AC: NX_P42166, NX_P42167

UniProt: P42166, P42167
Chr Location

12q23.1; chr12:98515573-98550351 (+) GRCh38

MGI Vertebrate Homology

Tmpo stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMPO
Gene Tree

Tmpo

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

24
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Tmpo
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous null for a protein isoform generated from this locus have hyperproliferation of epidermal and erythroid progenitor cells that leads to thickened paws and increased crypt lengths in the colon.

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All GO Annotations

12
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1027
Tissues

187
cDNA Data

42
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmpo

ZFIN tmpoa, tmpob

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All Sequences

127
RefSeq

29
UniProt

8
CCDS

CCDS24122.1, CCDS36032.1, CCDS36033.1, CCDS36034.1, CCDS36035.1

Ensembl

ENSMUSG00000019961 (Evidence)
NCBI Gene

21917

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019961	Ensembl Gene Model \| MGI Sequence Detail	33745	C57BL/6J	± kb
transcript	ENSMUST00000020123	Ensembl \| MGI Sequence Detail	3772	Not Applicable
polypeptide	ENSMUSP00000020123	Ensembl \| MGI Sequence Detail	693	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000029585 lamina-associated polypeptide 2

(term hierarchy)
PDB

2V0X
InterPro Domains

IPR021623 Lamina-associated polypeptide 2 alpha, C-terminal

IPR003887 LEM domain

IPR051656 LEM domain-containing

IPR011015 LEM/LEM-like domain superfamily

IPR013146 LEM-like domain
GlyGen

Q61033 3 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 54

Genomic 4

cDNA 43

Primer pair 6

Other 1

Microarray probesets 10

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MGD-MRK-35381, MGI:1918700, MGI:2143540, MGI:2143653, MGI:2143828, MGI:2143858

Summaries

All 71

Developmental Gene Expression 18

Gene Ontology 9

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:322547 Sidorenko E, et al., Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity. Sci Rep. 2022 Feb 10;12(1):2306

TSS for Tmpo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98918	Chr10:91007564-91007577 (-)	9,606 bp
Tssr98917	Chr10:91007387-91007472 (-)	9,747 bp
Tssr98916	Chr10:91007374-91007385 (-)	9,797 bp
Tssr98915	Chr10:91006503-91006507 (-)	10,672 bp
Tssr98914	Chr10:91006450-91006460 (-)	10,722 bp
Tssr98913	Chr10:91006362-91006390 (-)	10,801 bp
Tssr98912	Chr10:91006310-91006349 (-)	10,847 bp
Tssr98911	Chr10:90989711-90989718 (-)	27,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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