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Scn2b Gene Detail
Summary
  • Symbol
    Scn2b
  • Name
    sodium channel, voltage-gated, type II, beta
  • Synonyms
    2810451E09Rik, LOC214238
  • Feature Type
    protein coding gene
  • IDs
    MGI:106921
    NCBI Gene: 72821
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45029174-45041368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106921
 protein coding gene Chr9:45029080-45041368 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034731
 protein coding gene Chr9:43660790-43674797 (+)
A/J MGP_AJ_G0034712
 protein coding gene Chr9:42443395-42456376 (+)
AKR/J MGP_AKRJ_G0034639
 protein coding gene Chr9:43319187-43330508 (+)
BALB/cJ MGP_BALBcJ_G0034703
 protein coding gene Chr9:42176920-42189769 (+)
C3H/HeJ MGP_C3HHeJ_G0034414
 protein coding gene Chr9:43773470-43787339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035224
 protein coding gene Chr9:44937739-44952797 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032138
 protein coding gene Chr9:41995227-42007480 (+)
CAST/EiJ MGP_CASTEiJ_G0033736
 protein coding gene Chr9:43634076-43646258 (+)
CBA/J MGP_CBAJ_G0034386
 protein coding gene Chr9:46590890-46603076 (+)
DBA/2J MGP_DBA2J_G0034545
 protein coding gene Chr9:42332442-42344640 (+)
FVB/NJ MGP_FVBNJ_G0034486
 protein coding gene Chr9:41590641-41601921 (+)
LP/J MGP_LPJ_G0034626
 protein coding gene Chr9:43959792-43972500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034530
 protein coding gene Chr9:48412318-48424557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035245
 protein coding gene Chr9:43237761-43250643 (+)
PWK/PhJ MGP_PWKPhJ_G0033441
 protein coding gene Chr9:42219183-42232110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033277
 protein coding gene Chr9:43526796-43541799 (+)
WSB/EiJ MGP_WSBEiJ_G0033849
 protein coding gene Chr9:43264750-43280096 (+)



Homology
more
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN2B, sodium voltage-gated channel beta subunit 2
  • Synonyms
    ATFB14
  • Links
    NCBI Gene ID: 6327
    neXtProt AC: NX_O60939
    UniProt: O60939

  • Chr Location
    11q23.3; chr11:118162806-118176639 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SCN2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests. Impaired glucose tolerance in homozygous mutant males is seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    7
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72821 NCBI Gene Model | MGI Sequence Detail 12195 C57BL/6J ±  kb
    transcript NM_001014761 RefSeq | MGI Sequence Detail 4562 C57BL/6  
    polypeptide Q56A07 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35382, MGI:1920071, MGI:2143131, MGI:2685029
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:45864 Isom LL, et al., Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell. 1995 Nov 3;83(3):433-42
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory