Melk MGI Mouse Gene Detail - MGI:106924 - maternal embryonic leucine zipper kinase

Symbol

Melk
Name

maternal embryonic leucine zipper kinase
Synonyms

mKIAA0175, MPK38

Feature Type

protein coding gene
IDs

MGI:106924
NCBI Gene: 17279
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:44300876-44364301 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.46 cM
Mapping Data

4 experiments

SNPs within 2kb

1800 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106924	protein coding gene	Chr4:44300876-44364675 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028234	protein coding gene	Chr4:42471363-42532311 (+)
A/J	MGP_AJ_G0028191	protein coding gene	Chr4:40961660-41023534 (+)
AKR/J	MGP_AKRJ_G0028143	protein coding gene	Chr4:41917693-41975903 (+)
BALB/cJ	MGP_BALBcJ_G0028211	protein coding gene	Chr4:41046984-41110145 (+)
C3H/HeJ	MGP_C3HHeJ_G0027933	protein coding gene	Chr4:42536794-42597067 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028652	protein coding gene	Chr4:44088949-44153768 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025962	protein coding gene	Chr4:38379188-38434573 (+)
CAST/EiJ	MGP_CASTEiJ_G0027372	protein coding gene	Chr4:42052781-42115438 (+)
CBA/J	MGP_CBAJ_G0027899	protein coding gene	Chr4:45455771-45526533 (+)
DBA/2J	MGP_DBA2J_G0028048	protein coding gene	Chr4:40857635-40919788 (+)
FVB/NJ	MGP_FVBNJ_G0028015	protein coding gene	Chr4:40090756-40147954 (+)
LP/J	MGP_LPJ_G0028147	protein coding gene	Chr4:42543874-42603757 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028039	protein coding gene	Chr4:48639005-48705334 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028688	protein coding gene	Chr4:42131402-42197179 (+)
PWK/PhJ	MGP_PWKPhJ_G0027096	protein coding gene	Chr4:40906232-40965551 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026925	protein coding gene	Chr4:41654101-41715476 (+)
WSB/EiJ	MGP_WSBEiJ_G0027450	protein coding gene	Chr4:42008433-42068576 (+)

Human Ortholog

MELK, maternal embryonic leucine zipper kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MELK, maternal embryonic leucine zipper kinase
Synonyms

HPK38
Links

HGNC:16870

NCBI Gene ID: 9833

neXtProt AC: NX_Q14680

UniProt: Q14680
Chr Location

9p13.2; chr9:36572862-36677683 (+) GRCh38

MGI Vertebrate Homology

Melk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MELK
Gene Tree

Melk

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

4
Gene trapped

8
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an allele that produces a kinase-dead protein exhibit altered pancreatic regeneration following injury.

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All GO Annotations

32
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1189
Tissues

190
cDNA Data

101
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase melk

ZFIN melk

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All Sequences

63
RefSeq

8
UniProt

6
CCDS

CCDS18124.1

Ensembl

ENSMUSG00000035683 (Evidence)
NCBI Gene

17279

			Length	Strain/Species	Flank
genomic	17279	NCBI Gene Model \| MGI Sequence Detail	63426	C57BL/6J	± kb
transcript	NM_010790	RefSeq \| MGI Sequence Detail	2501	ZRU/MplStud
polypeptide	Q61846	UniProt \| EBI \| MGI Sequence Detail	643	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010319 maternal embryonic leucine zipper kinase

(term hierarchy)
PDB

4BFM, 4CQG
EC

2.7.10.2, 2.7.11.1
InterPro Domains

IPR028375 KA1 domain/Ssp2, C-terminal

IPR001772 Kinase associated domain 1 (KA1)

IPR034673 Maternal embryonic leucine zipper kinase, catalytic domain

IPR048637 Maternal embryonic leucine zipper kinase, UBA domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q61846 1 site, 1 O-linked glycan (1 site)

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All nucleic 107

cDNA 103

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-35385, MGI:2140251

Summaries

All 54

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 11
Earliest

J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Melk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37023	Chr4:44300903-44300936 (+)	44 bp
Tssr37024	Chr4:44300940-44301002 (+)	95 bp
Tssr1159	Chr4:44328909-44328913 (+)	28,035 bp
Tssr37025	Chr4:44337822-44337826 (+)	36,948 bp
Tssr1160	Chr4:44362269-44362270 (+)	61,394 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24