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Cldn11 Gene Detail
Summary
  • Symbol
    Cldn11
  • Name
    claudin 11
  • Synonyms
    oligodendrocyte-specific protein, Osp, Otm
  • Feature Type
    protein coding gene
  • IDs
    MGI:106925
    NCBI Gene: 18417
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31204069-31218473 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106925
 protein coding gene Chr3:31204069-31218475 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027132
 protein coding gene Chr3:28678017-28693270 (+)
A/J MGP_AJ_G0027092
 protein coding gene Chr3:28299656-28314724 (+)
AKR/J MGP_AKRJ_G0027061
 protein coding gene Chr3:28733347-28749512 (+)
BALB/cJ MGP_BALBcJ_G0027104
 protein coding gene Chr3:27984813-27999957 (+)
C3H/HeJ MGP_C3HHeJ_G0026846
 protein coding gene Chr3:28748321-28771208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027550
 protein coding gene Chr3:30196772-30215504 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024911
 protein coding gene Chr3:26200451-26214525 (+)
CAST/EiJ MGP_CASTEiJ_G0026300
 protein coding gene Chr3:28673764-28691246 (+)
CBA/J MGP_CBAJ_G0026824
 protein coding gene Chr3:30956321-30970723 (+)
DBA/2J MGP_DBA2J_G0026958
 protein coding gene Chr3:27844541-27858970 (+)
FVB/NJ MGP_FVBNJ_G0026926
 protein coding gene Chr3:27293078-27307612 (+)
LP/J MGP_LPJ_G0027069
 protein coding gene Chr3:29374477-29402814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026946
 protein coding gene Chr3:33535204-33549938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027609
 protein coding gene Chr3:28512943-28528865 (+)
PWK/PhJ MGP_PWKPhJ_G0026033
 protein coding gene Chr3:27363277-27378336 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025845
 protein coding gene Chr3:27999456-28014937 (+)
WSB/EiJ MGP_WSBEiJ_G0026374
 protein coding gene Chr3:28573523-28593784 (+)



Homology
more
  • Human Ortholog
    CLDN11, claudin 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN11, claudin 11
  • Synonyms
    HLD22, OSP, OTM
  • Links
    NCBI Gene ID: 5010
    neXtProt AC: NX_O75508
    UniProt: O75508

  • Chr Location
    3q26.2; chr3:170418868-170454733 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLDN11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit tremors, impaired coordination, hindlimb weakness, abnormal myelination of the cranial nerves, increased auditory thresholds, and abnormal stria vascularis. Mutant males have small testes, abnormal seminiferous tubules, and sperm abnormalities resulting in infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    983
  • Tissues
    75
  • cDNA Data
    23
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037625 Ensembl Gene Model | MGI Sequence Detail 14405 C57BL/6J ±  kb
    transcript ENSMUST00000046174 Ensembl | MGI Sequence Detail 1870 Not Applicable  
    polypeptide ENSMUSP00000042181 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 23
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35386
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 50
      Diseases 1
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:33372 Bronstein JM, et al., Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996 Jun 1;34(2):255-7
    • Latest
      J:347284 Zhang Y, et al., PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Rep. 2024 Mar 26;43(3):113930
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory