Ppp3cc MGI Mouse Gene Detail - MGI:107162 - protein phosphatase 3, catalytic subunit, gamma isoform

Symbol

Ppp3cc
Name

protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms

Calnc, PP2BA gamma

Feature Type

protein coding gene
IDs

MGI:107162
NCBI Gene: 19057
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:70455314-70526920 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.30 cM
Mapping Data

2 experiments

SNPs within 2kb

1554 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107162	protein coding gene	Chr14:70455314-70526979 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021534	protein coding gene	Chr14:64846132-64932622 (-)
A/J	MGP_AJ_G0021493	protein coding gene	Chr14:63481708-63554216 (-)
AKR/J	MGP_AKRJ_G0021469	protein coding gene	Chr14:65385928-65460577 (-)
BALB/cJ	MGP_BALBcJ_G0021499	protein coding gene	Chr14:63246530-63318181 (-)
C3H/HeJ	MGP_C3HHeJ_G0021276	protein coding gene	Chr14:65096665-65173466 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021938	protein coding gene	Chr14:67760873-67836498 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019478	protein coding gene	Chr14:61318724-61391684 (-)
CAST/EiJ	MGP_CASTEiJ_G0020793	protein coding gene	Chr14:61684259-61761821 (-)
CBA/J	MGP_CBAJ_G0021243	protein coding gene	Chr14:69879355-69962838 (-)
DBA/2J	MGP_DBA2J_G0021366	protein coding gene	Chr14:62864731-62936949 (-)
FVB/NJ	MGP_FVBNJ_G0021345	protein coding gene	Chr14:62293093-62364869 (-)
LP/J	MGP_LPJ_G0021437	protein coding gene	Chr14:66096520-66174171 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021374	protein coding gene	Chr14:68791797-68866932 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021962	protein coding gene	Chr14:64647102-64722069 (-)
PWK/PhJ	MGP_PWKPhJ_G0020537	protein coding gene	Chr14:59627021-59702239 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020370	protein coding gene	Chr14:60578574-60652773 (-)
WSB/EiJ	MGP_WSBEiJ_G0020846	protein coding gene	Chr14:64956105-65034142 (-)

Human Ortholog

PPP3CC, protein phosphatase 3 catalytic subunit gamma

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP3CC, protein phosphatase 3 catalytic subunit gamma
Synonyms

CALNA3, CNA3, PP2Bgamma
Links

HGNC:9316

NCBI Gene ID: 5533

neXtProt AC: NX_P48454

UniProt: P48454
Chr Location

8p21.3; chr8:22440819-22541142 (+) GRCh38

MGI Vertebrate Homology

Ppp3cc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP3CC
Gene Tree

Ppp3cc

Diseases

1 with human PPP3CC associations

				Human Disease	Mouse Models
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Transgenic

3
Genomic Mutations

1 involving Ppp3cc
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility due to reduced hyperactivated sperm motility and midpiece rigidity.

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All GO Annotations

48
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

19
cDNA Data

37
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp3cb

ZFIN ppp3cca, ppp3ccb

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All Sequences

70
RefSeq

33
UniProt

4
CCDS

CCDS36968.1, CCDS88703.1

Ensembl

ENSMUSG00000022092 (Evidence)
NCBI Gene

19057

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022092	Ensembl Gene Model \| MGI Sequence Detail	71607	C57BL/6J	± kb
transcript	ENSMUST00000228911	Ensembl \| MGI Sequence Detail	1836	Not Applicable
polypeptide	ENSMUSP00000153725	Ensembl \| MGI Sequence Detail	522	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013149 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR004843 Calcineurin-like phosphoesterase domain, ApaH type

IPR029052 Metallo-dependent phosphatase-like

IPR043360 PP2B

IPR041751 PP2B, metallophosphatase domain

IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

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All nucleic 39

cDNA 37

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-1738, MGD-MRK-35623

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 18

Phenotypes 12
Earliest

J:32280 Kincaid RL, et al., Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp3cc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129568	Chr14:70526879-70526958 (-)	1 bp
Tssr129567	Chr14:70526865-70526878 (-)	48 bp
Tssr4469	Chr14:70526854-70526861 (-)	62 bp
Tssr129566	Chr14:70517321-70517355 (-)	9,582 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24