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Ppp3ca Gene Detail
Summary
  • Symbol
    Ppp3ca
  • Name
    protein phosphatase 3, catalytic subunit, alpha isoform
  • Synonyms
    2900074D19Rik, Caln, Calna, CN, CnA, PP2BA alpha, PP2B alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107164
    NCBI Gene: 19055
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:136375885-136643488 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 63.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7507 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107164
 protein coding gene Chr3:136375778-136643488 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027913
 protein coding gene Chr3:139644747-139922903 (+)
A/J MGP_AJ_G0027870
 protein coding gene Chr3:134731125-135003025 (+)
AKR/J MGP_AKRJ_G0027836
 protein coding gene Chr3:138286386-138565730 (+)
BALB/cJ MGP_BALBcJ_G0027883
 protein coding gene Chr3:134553678-134830554 (+)
C3H/HeJ MGP_C3HHeJ_G0027612
 protein coding gene Chr3:138617857-138900566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028326
 protein coding gene Chr3:144475207-144764704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025664
 protein coding gene Chr3:129884133-130150904 (+)
CAST/EiJ MGP_CASTEiJ_G0027068
 protein coding gene Chr3:138379370-138667419 (+)
CBA/J MGP_CBAJ_G0027589
 protein coding gene Chr3:149400064-149710364 (+)
DBA/2J MGP_DBA2J_G0027728
 protein coding gene Chr3:133851106-134120573 (+)
FVB/NJ MGP_FVBNJ_G0027695
 protein coding gene Chr3:131322037-131592340 (+)
LP/J MGP_LPJ_G0027838
 protein coding gene Chr3:141050183-141339669 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027727
 protein coding gene Chr3:157511894-157801922 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028384
 protein coding gene Chr3:137809585-138087257 (+)
PWK/PhJ MGP_PWKPhJ_G0026792
 protein coding gene Chr3:133585137-133867442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026619
 protein coding gene Chr3:135903636-136187485 (+)
WSB/EiJ MGP_WSBEiJ_G0027148
 protein coding gene Chr3:138634737-138918206 (+)



Homology
more
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP3CA, protein phosphatase 3 catalytic subunit alpha
  • Synonyms
    ACCIID, CALN, CALNA, CALNA1, CCN1, CNA1, DEE91, IECEE, IECEE1, PPP2B
  • Links
    NCBI Gene ID: 5530
    neXtProt AC: NX_Q08209
    UniProt: Q08209

  • Chr Location
    4q24; chr4:101023409-101348278 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppp3ca mouse models; 1 with human PPP3CA associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased T cell proliferation and abnormal mossy fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    142
  • GO References
    58
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    77
  • cDNA Data
    22
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028161 Ensembl Gene Model | MGI Sequence Detail 267604 C57BL/6J ±  kb
    transcript ENSMUST00000056758 Ensembl | MGI Sequence Detail 2194 Not Applicable  
    polypeptide ENSMUSP00000053101 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003278 protein phosphatase 3 catalytic subunit alpha
      (term hierarchy)
    • PDB
      4ORB
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR043360 PP2B
      IPR041751 PP2B, metallophosphatase domain
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    • GlyGen
      P63328 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 22
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1735, MGD-MRK-1736, MGD-MRK-35625, MGI:1920287, MGI:2139807, MGI:2139982
    References
    more
    • Summaries
      All 241
      Developmental Gene Expression 22
      Diseases 2
      Gene Ontology 58
      Phenotypes 95
    • Earliest
      J:9480 Kincaid RL, et al., Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin. Proc Natl Acad Sci U S A. 1988 Dec;85(23):8983-7
    • Latest
      J:348385 Eden M, et al., Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy. J Biol Chem. 2024 Apr 3;300(5):107255
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory