Fosl1 MGI Mouse Gene Detail - MGI:107179

Symbol

Fosl1
Name

fos-like antigen 1
Synonyms

fra-1, Fra1

Feature Type

protein coding gene
IDs

MGI:107179
NCBI Gene: 14283
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr19:5497726-5505966 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.33 cM
Mapping Data

7 experiments

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107179	protein coding gene	Chr19:5497575-5505974 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024706	protein coding gene	Chr19:2416940-2425183 (+)
A/J	MGP_AJ_G0024672	protein coding gene	Chr19:2282360-2290591 (+)
AKR/J	MGP_AKRJ_G0024645	protein coding gene	Chr19:2340268-2348497 (+)
BALB/cJ	MGP_BALBcJ_G0024672	protein coding gene	Chr19:2274939-2284334 (+)
C3H/HeJ	MGP_C3HHeJ_G0024440	protein coding gene	Chr19:2349834-2358065 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025119	protein coding gene	Chr19:2470854-2480774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022549	protein coding gene	Chr19:2184207-2192725 (+)
CAST/EiJ	MGP_CASTEiJ_G0023912	protein coding gene	Chr19:2377209-2385457 (+)
CBA/J	MGP_CBAJ_G0024412	protein coding gene	Chr19:2581386-2590164 (+)
DBA/2J	MGP_DBA2J_G0024539	protein coding gene	Chr19:2261356-2269969 (+)
FVB/NJ	MGP_FVBNJ_G0024506	protein coding gene	Chr19:2268517-2276750 (+)
LP/J	MGP_LPJ_G0024625	protein coding gene	Chr19:2396377-2404647 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024536	protein coding gene	Chr19:2435624-2444836 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025167	protein coding gene	Chr19:2357062-2366320 (+)
PWK/PhJ	MGP_PWKPhJ_G0023658	protein coding gene	Chr19:2298450-2306871 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023463	protein coding gene	Chr19:2340034-2348452 (+)
WSB/EiJ	MGP_WSBEiJ_G0023974	protein coding gene	Chr19:2368973-2377238 (+)

Human Ortholog

FOSL1, FOS like 1, AP-1 transcription factor subunit

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOSL1, FOS like 1, AP-1 transcription factor subunit
Synonyms

FRA, fra-1, FRA1
Links

HGNC:13718

NCBI Gene ID: 8061

neXtProt AC: NX_P15407

UniProt: P15407
Chr Location

11q13.1; chr11:65892049-65900573 (-) GRCh38

MGI Vertebrate Homology

Fosl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FOSL1
Gene Tree

Fosl1

Diseases

1 with human FOSL1 associations

				Human Disease	Mouse Models
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

62 phenotypes from 5 alleles in 5 genetic backgrounds
18 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

6
Transgenic

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer.

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

130
cDNA Data

24
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fosl1

ZFIN fosl1a, fosl1b

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All Sequences

40
RefSeq

2
UniProt

5
CCDS

CCDS29464.1

Ensembl

ENSMUSG00000024912 (Evidence)
NCBI Gene

14283

			Length	Strain/Species	Flank
genomic	14283	NCBI Gene Model \| MGI Sequence Detail	8241	C57BL/6J	± kb
transcript	NM_010235	RefSeq \| MGI Sequence Detail	1705	ZRU/MplStud
polypeptide	P48755	UniProt \| EBI \| MGI Sequence Detail	273	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007599 Fos-related antigen 1

(term hierarchy)
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily
GlyGen

P48755 1 site, 1 O-linked glycan (1 site)

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All nucleic 33

Genomic 1

cDNA 25

Primer pair 7

Microarray probesets 4

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MGD-MRK-35640, MGI:2147739

Summaries

All 86

Developmental Gene Expression 19

Diseases 1

Gene Ontology 8

Phenotypes 31
Earliest

J:23980 Carrasco D, et al., Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development. Oncogene. 1995 Mar 16;10(6):1069-79
Latest

J:354109 Bakiri L, et al., Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc. Proc Natl Acad Sci U S A. 2024;

TSS for Fosl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154419	Chr19:5497720-5497739 (+)	4 bp
Tssr5411	Chr19:5497752-5497757 (+)	29 bp
Tssr154420	Chr19:5497887-5497894 (+)	165 bp
Tssr154421	Chr19:5497914-5497933 (+)	198 bp
Tssr154422	Chr19:5500261-5500310 (+)	2,560 bp
Tssr154423	Chr19:5504451-5504457 (+)	6,728 bp
Tssr154424	Chr19:5505077-5505096 (+)	7,361 bp
Tssr154425	Chr19:5505618-5505640 (+)	7,903 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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