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Ccr5 Gene Detail
Summary
  • Symbol
    Ccr5
  • Name
    C-C motif chemokine receptor 5
  • Synonyms
    CD195, Cmkbr5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107182
    NCBI Gene: 12774
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123921557-123934153 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107182
 protein coding gene Chr9:123921557-123947736 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035493
 protein coding gene Chr9:127250058-127260327 (+)
A/J MGP_AJ_G0035471
 protein coding gene Chr9:122336278-122362219 (+)
AKR/J MGP_AKRJ_G0035404
 protein coding gene Chr9:125604074-125629422 (+)
BALB/cJ MGP_BALBcJ_G0035467
 protein coding gene Chr9:122268068-122293931 (+)
C3H/HeJ MGP_C3HHeJ_G0035174
 protein coding gene Chr9:126055978-126066228 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035990
 protein coding gene Chr9:130695430-130722533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032872
 protein coding gene Chr9:119769490-119779943 (+)
CAST/EiJ MGP_CASTEiJ_G0034479
 protein coding gene Chr9:126064624-126091404 (+)
CBA/J MGP_CBAJ_G0035142
 protein coding gene Chr9:135513573-135523851 (+)
DBA/2J MGP_DBA2J_G0035301
 protein coding gene Chr9:121827013-121837241 (+)
FVB/NJ MGP_FVBNJ_G0035248
 protein coding gene Chr9:120670832-120681144 (+)
LP/J MGP_LPJ_G0035380
 protein coding gene Chr9:127628062-127638341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035289
 protein coding gene Chr9:136330493-136357217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036009
 protein coding gene Chr9:126097701-126124876 (+)
PWK/PhJ MGP_PWKPhJ_G0034183
 protein coding gene Chr9:122224914-122235373 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034021
 protein coding gene Chr9:126127141-126156895 (+)
WSB/EiJ MGP_WSBEiJ_G0034599
 protein coding gene Chr9:125877739-125907963 (+)



Homology
more
  • Human Ortholog
    CCR5, C-C motif chemokine receptor 5
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR5, C-C motif chemokine receptor 5
  • Synonyms
    CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
  • Links
    NCBI Gene ID: 1234
    neXtProt AC: NX_P51681
    UniProt: P51681

  • Chr Location
    3p21.31; chr3:46370142-46376206 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccr5 mouse models; 24 with human CCR5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 4 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    235 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are homozygous for null alleles have leukocytes with defective migration and adhesion, are more susceptibility to fungal & bacterial infections, have increased length of allograft survival, and have decreased susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    72
  • cDNA Data
    52
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12774 NCBI Gene Model | MGI Sequence Detail 12597 C57BL/6J ±  kb
    transcript NM_009917 RefSeq | MGI Sequence Detail 2926 ZRU/MplStud  
    polypeptide P51682 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 2
      cDNA 52
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35643
    References
    more
    • Summaries
      All 306
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 16
      Phenotypes 235
    • Earliest
      J:32263 Boring L, et al., Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J Biol Chem. 1996 Mar 29;271(13):7551-8
    • Latest
      J:358846 Ren XS, et al., Hematopoietic Growth Factors Regulate the Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5. Int J Mol Sci. 2024 Aug 15;25(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory